KRAB-associated C2H2 zinc-finger (KRAB-ZNF) proteins are the products of a rapidly evolving gene family that traces back to early tetrapods, but which has expanded dramatically to generate an unprecedented level of species-specific diversity. While most attention has been focused on the more recently evolved primate KRAB-ZNF genes, the vertebrate roots of the KRAB-ZNF families have remained mysterious. We recently mined ZNF loci from seven sequenced genomes (opossum, chicken, zebra finch, lizard, frog, mouse, and human genome) and found hundreds of KRAB-ZNF proteins in every species we examined, but only three human genes were found with clear orthologs in non-mammalian vertebrates. These three genes, ZNF777, ZNF282, and ZNF783, are members...
The KRAB-containing zinc finger (KRAB-ZF) proteins represent the largest family of transcription fac...
AbstractWe report the characterization of three novel members of the KRAB-domain-containing C2H2 zi...
Throughout evolution primate genomes have been modified by waves of retrotransposon insertions. For ...
KRAB-associated C2H2 zinc-finger (KRAB-ZNF) proteins are the products of a rapidly evolving gene fam...
Krüppel-type zinc finger (ZNF) motifs are prevalent components of transcription factor proteins in a...
Krueppel-type zinc finger (ZNF) motifs are prevalent components of transcription factor proteins in ...
International audienceBACKGROUND: Expansion of multi-C2H2 domain zinc finger (ZNF) genes, including ...
Neurogenesis, and the processes through which neural stem cells and progenitor cells differentiate i...
Kruppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcripti...
KRAB-containing poly-zinc finger proteins (KZFPs) constitute the largest family of transcription fac...
Highly coordinated transcription networks orchestrate the self-renewal of pluripotent stem cell and ...
ZNF675 is a primate-specific KRAB-ZNF protein that arose in the last common ancestor of New World Mo...
All living organisms consist of cells and the identity of a cell is defined by the genes it expresse...
Certain subfamilies of zinc finger transcription factors (ZNF-TFs), especially those including KRAB ...
Krüppel-related zinc finger proteins constitute the largest single class of transcription factors wi...
The KRAB-containing zinc finger (KRAB-ZF) proteins represent the largest family of transcription fac...
AbstractWe report the characterization of three novel members of the KRAB-domain-containing C2H2 zi...
Throughout evolution primate genomes have been modified by waves of retrotransposon insertions. For ...
KRAB-associated C2H2 zinc-finger (KRAB-ZNF) proteins are the products of a rapidly evolving gene fam...
Krüppel-type zinc finger (ZNF) motifs are prevalent components of transcription factor proteins in a...
Krueppel-type zinc finger (ZNF) motifs are prevalent components of transcription factor proteins in ...
International audienceBACKGROUND: Expansion of multi-C2H2 domain zinc finger (ZNF) genes, including ...
Neurogenesis, and the processes through which neural stem cells and progenitor cells differentiate i...
Kruppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcripti...
KRAB-containing poly-zinc finger proteins (KZFPs) constitute the largest family of transcription fac...
Highly coordinated transcription networks orchestrate the self-renewal of pluripotent stem cell and ...
ZNF675 is a primate-specific KRAB-ZNF protein that arose in the last common ancestor of New World Mo...
All living organisms consist of cells and the identity of a cell is defined by the genes it expresse...
Certain subfamilies of zinc finger transcription factors (ZNF-TFs), especially those including KRAB ...
Krüppel-related zinc finger proteins constitute the largest single class of transcription factors wi...
The KRAB-containing zinc finger (KRAB-ZF) proteins represent the largest family of transcription fac...
AbstractWe report the characterization of three novel members of the KRAB-domain-containing C2H2 zi...
Throughout evolution primate genomes have been modified by waves of retrotransposon insertions. For ...