In Vivo Interaction Between Health Food Supplements and Chemotherapeutic Agents on DNA Damage and Cell Production

125 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.As expected, both Ara-C and MMS treated mice had DNA and cellular damage. SW, FL, Soy and RM10 were found to cause alterations of DNA and/or cellular damage. SW affected to increase genotoxicity of bone marrow while the increased percentage of reticulocytes was observed. FL and RM10 were found to interact with Ara-C. Either the interaction of FL or RM10 with Ara-C resulted in decreased genotoxicity to bone marrow cells. Soy affected to decrease genotoxicity of erythocytes. These results demonstrate that over-the-counter health supplements can alter of DNA and cause cell damage and can interact with chemotherapeutic agents, and that flow cytometric analysis is a rapid and reliable technique for screening the cytotoxic and genotoxic effects of these products.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD