Developmentally Related Increased Seizure Susceptibility to Pentylenetetrazole in Fragile X Knockout Mice

112 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.These experiments have demonstrated that fragile X knockout mice are more susceptible than control animals to the chemoconvulsant PTZ as adults, but not as juveniles. Furthermore, the temporal progression suggests that there is a developmental involvement in this seizure susceptibility. The mechanism of the seizure susceptibility and temporal progression are areas for further study. With a greater understanding of this general hyperexcitability, more effective treatments for fragile X patients can be devised.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD