The fact that innovative activity is remarkably concentrated in space, and in particular in cities, has motivated an important research effort to understand the spatial dimension of innovation, and the underlying mechanisms at work. While the literature has established the importance knowledge flows for location of innovation, the mechanisms through which they diffuse in space remain largely understudied. In particular, studies have insisted on the importance of skilled workers' mobility and the networked nature of knowledge production for innovation. Building on these considerations, this thesis investigates the role of skilled mobility in the diffusion of knowledge, and the resulting distribution of innovative activity. To answer this q...