Effect of mTOR silencing in mouse infralimbic cortex on depressive-like behaviour

Póster presentado al 30th ECNP Congress: "For the science and treatment of disorders of the brain", celebrado en Paris del 2 al 5 de septiembre de 2017.Among the hypotheses postulated with the aim of clarifying the neurobiological basis of major depressive disorder (MDD), the neurotrophic hypothesis is one of the most accepted. The extremely important role of trophic factors such as the brain derived neurotrophic factor (BNDF) in both, the etiopatology and the antidepressant effect, is well known. However, in recent decades, the intracellular pathways related to neural proliferation and plasticity have gained strength in the field. In this regard, increased activation of mammalian target of rapamycin (mTOR) pathway in the medial prefrontal cortex (mPFC), is necessary for the rapid antidepressant effect of the NMethyl-D-aspartate (NMDA) antagonist ketamine.Supported by Spanish Ministry of Economy and Competitiveness (SAF2011-25020 and SAF2015-67457-R).Peer Reviewe