Abietane-type diterpenoids, either naturally occurring or synthetic, have shown a wide range of pharmacological actions, including antiprotozoal properties. In this study, we report on the antileishmanial evaluation of a series of (+)-dehydroabietylamine derivatives functionalized at C7 and/or C12. Thus, the activity in vitro against Leishmania infantum, Leishmania donovani, Leishmania amazonensis and Leishmania guyanensis, was studied. Most of the benzamide derivatives showed activities at low micromolar concentration against cultured promastigotes of Leishmania spp. (IC50 = 2.2–46.8 μM), without cytotoxicity on J774 macrophage cells. Compound 15, an acetamide, was found to be the most active leishmanicidal agent, though it presented some ...
According to the WHO, infectious diseases, and in particular neglected tropical diseases in poor dev...
Dicationic diamidines synthesized in the Boykin group a have shown broad range of activity against a...
Within this work, we describe the design and synthesis of a range of novel thiochromanones based on ...
Abietane-type diterpenoids, either naturally occurring or synthetic, have shown a wide range of phar...
Dehydroabietylamine (1) was used as a starting material to synthesize a small library of dehydroabie...
Dehydroabietylamine (1) was used as a starting material to synthesize a small library of dehydroabie...
Dehydroabietylamine (1) was used as a starting material to synthesize a small library of dehydroabie...
Dehydroabietylamine (<b>1</b>) was used as a starting material to synthesize a small library of dehy...
Introduction and Goal Leishmaniasis is widespread in many parts of the world, with the prevalence i...
Background and purpose: The prevalence of leishmaniasis is reported in more than 98 countries and Ir...
WOS:000428824700013In continuation to our previous findings on amidoximes' antiparasitic activities,...
WOS:000428824700013In continuation to our previous findings on amidoximes' antiparasitic activities,...
WOS:000428824700013In continuation to our previous findings on amidoximes' antiparasitic activities,...
Background and purpose: The prevalence of leishmaniasis is reported in more than 98 countries and Ir...
WOS:000428824700013In continuation to our previous findings on amidoximes' antiparasitic activities,...
According to the WHO, infectious diseases, and in particular neglected tropical diseases in poor dev...
Dicationic diamidines synthesized in the Boykin group a have shown broad range of activity against a...
Within this work, we describe the design and synthesis of a range of novel thiochromanones based on ...
Abietane-type diterpenoids, either naturally occurring or synthetic, have shown a wide range of phar...
Dehydroabietylamine (1) was used as a starting material to synthesize a small library of dehydroabie...
Dehydroabietylamine (1) was used as a starting material to synthesize a small library of dehydroabie...
Dehydroabietylamine (1) was used as a starting material to synthesize a small library of dehydroabie...
Dehydroabietylamine (<b>1</b>) was used as a starting material to synthesize a small library of dehy...
Introduction and Goal Leishmaniasis is widespread in many parts of the world, with the prevalence i...
Background and purpose: The prevalence of leishmaniasis is reported in more than 98 countries and Ir...
WOS:000428824700013In continuation to our previous findings on amidoximes' antiparasitic activities,...
WOS:000428824700013In continuation to our previous findings on amidoximes' antiparasitic activities,...
WOS:000428824700013In continuation to our previous findings on amidoximes' antiparasitic activities,...
Background and purpose: The prevalence of leishmaniasis is reported in more than 98 countries and Ir...
WOS:000428824700013In continuation to our previous findings on amidoximes' antiparasitic activities,...
According to the WHO, infectious diseases, and in particular neglected tropical diseases in poor dev...
Dicationic diamidines synthesized in the Boykin group a have shown broad range of activity against a...
Within this work, we describe the design and synthesis of a range of novel thiochromanones based on ...