To directly define the role of phospholipase Cγ1 (PLCγ1) in NF-κB activation, NF-κB promoted luciferase reporter gene plasmid (pNF-κB-Luc) was transfected into rat-3Y1 fibroblasts that overexpress whole PLCγ1 (PLCγ1-3Y1), src homology domains SH2-SH2-SH3 of PLCγ1 (SH223-3Y1) and v-src (Src-3Y1). Transient transfection with pNF-κB-Luc remarkably increased the luciferase activity in all three transformants compared with normal rat-3Y1 cells. Pretreatment with inhibitors of protein tyrosine kinase reduced this increase in luciferase activity, but U73122 (a PLC inhibitor) did not. While PD98059, an inhibitor of mitogen activated protein kinase (MAPK), significantly reduced the luciferase activity, there was no effect by wortmannin and Ro-31-822...
Phospholipase C-gamma 1 (PLC-gamma l) mediates signals from various extracellular origins to evoke c...
The phospholipase C (PLC) family of cellular proteins participates in the intracellular signaling me...
Phospholipase C β1 (PLCβ1) is known to play an important role in cell proliferation. Previous studie...
To directly define the role of phospholipase Cγ1 (PLCγ1) in NF-κB activation, NF-κB promoted lucifer...
To directly define the role of phospholipase C gamma 1 (PLC gamma 1) in NF-kappa B activation, NF-ka...
AbstractTo directly define the role of phospholipase Cγ1 (PLCγ1) in NF-κB activation, NF-κB promoted...
AbstractPhospholipase activity is elevated in dividing cells. In response to growth factor stimulati...
Src homology (SH) 2 and 3 domains are known to be binding motifs for protein-protein interaction in ...
Alterations in the production and regulation of lipid second messengers can give rise to key molecul...
The Shc3 domain of PLC-gamma 1 has been known to induce DNA synthesis. However, little is known abou...
Alterations in the production and regulation of lipid second messengers can give rise to key molecul...
Previously, we demonstrated that microinjection of phosphoinositide-specific phospholipase Cγy1 (PLC...
AbstractSrc homology 2 (SH2) domains on the regulatory subunit of phosphoinositide 3-kinase (PI 3-ki...
<p>A. Illustration of the predicted NF-κB binding site in human (top) or murine (bottom) <i>PIK3CA</...
<p>(A) Increasing amounts of the isolated PLCγ2 cSH2 domain gradually inhibit the interaction of K15...
Phospholipase C-gamma 1 (PLC-gamma l) mediates signals from various extracellular origins to evoke c...
The phospholipase C (PLC) family of cellular proteins participates in the intracellular signaling me...
Phospholipase C β1 (PLCβ1) is known to play an important role in cell proliferation. Previous studie...
To directly define the role of phospholipase Cγ1 (PLCγ1) in NF-κB activation, NF-κB promoted lucifer...
To directly define the role of phospholipase C gamma 1 (PLC gamma 1) in NF-kappa B activation, NF-ka...
AbstractTo directly define the role of phospholipase Cγ1 (PLCγ1) in NF-κB activation, NF-κB promoted...
AbstractPhospholipase activity is elevated in dividing cells. In response to growth factor stimulati...
Src homology (SH) 2 and 3 domains are known to be binding motifs for protein-protein interaction in ...
Alterations in the production and regulation of lipid second messengers can give rise to key molecul...
The Shc3 domain of PLC-gamma 1 has been known to induce DNA synthesis. However, little is known abou...
Alterations in the production and regulation of lipid second messengers can give rise to key molecul...
Previously, we demonstrated that microinjection of phosphoinositide-specific phospholipase Cγy1 (PLC...
AbstractSrc homology 2 (SH2) domains on the regulatory subunit of phosphoinositide 3-kinase (PI 3-ki...
<p>A. Illustration of the predicted NF-κB binding site in human (top) or murine (bottom) <i>PIK3CA</...
<p>(A) Increasing amounts of the isolated PLCγ2 cSH2 domain gradually inhibit the interaction of K15...
Phospholipase C-gamma 1 (PLC-gamma l) mediates signals from various extracellular origins to evoke c...
The phospholipase C (PLC) family of cellular proteins participates in the intracellular signaling me...
Phospholipase C β1 (PLCβ1) is known to play an important role in cell proliferation. Previous studie...