Bloodstream-form African trypanosomes encode two structurally related glycosylphosph ati- dylinositol (GPI)-anchored proteins that are critical virulence factors, variant surface glyco- protein (VSG) for antigenic variation and transferrin receptor (TfR) for iron acquisition. Both are transcribed from the active telomeric expression site. VSG is a GPI 2 homodimer; TfR is a GPI 1 heterodimer of GPI-anchored ESAG6 and ESAG7. GPI-valence correlates with secretory progression and fate in bloodstream trypanosom es: VSG (GPI 2 ) is a surface pro- tein; truncated VSG (GPI 0 ) is degraded in the lysosome; and native TfR (GPI 1 ) localizes in the flagellar pocket. Tf:Fe starvation results in up-regulation and redistribution of TfR to the plasma memb...
AbstractUptake of host transferrin (Tf) in Trypanosoma brucei is mediated by a heterodimeric, glycos...
African trypanosomes are highly divergent from their metazoan hosts, and as part of adaptation to a ...
To maintain prolonged infection of mammals, African trypanosomes have evolved remarkable surface coa...
Bloodstream-form African trypanosomes encode two structurally related glycosylphosphatidylinositol (...
The transferrin receptor of Trypanosoma brucei (TbTfR) is a heterodimer of a glycosylphosphatidylino...
African trypanosomes are extracellular protozoan pathogens that have evolved a complex and sophistic...
The transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expressi...
The transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expressi...
Recently we identified multiple suramin-sensitivity genes with a genome wide screen in Trypanosoma b...
Recently we identified multiple suramin-sensitivity genes with a genome wide screen in Trypanosoma b...
AbstractAfrican sleeping sickness is a debilitating and often fatal disease caused by tsetse fly tra...
Suramin was introduced into the clinic a century ago and is still used to treat the first stage of a...
Iron is an essential element for life. Its uptake and utility requires a careful balancing with its ...
The surface proteins of parasitic protozoa mediate functions essential to survival within a host, in...
AbstractUptake of host transferrin (Tf) in Trypanosoma brucei is mediated by a heterodimeric, glycos...
African trypanosomes are highly divergent from their metazoan hosts, and as part of adaptation to a ...
To maintain prolonged infection of mammals, African trypanosomes have evolved remarkable surface coa...
Bloodstream-form African trypanosomes encode two structurally related glycosylphosphatidylinositol (...
The transferrin receptor of Trypanosoma brucei (TbTfR) is a heterodimer of a glycosylphosphatidylino...
African trypanosomes are extracellular protozoan pathogens that have evolved a complex and sophistic...
The transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expressi...
The transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expressi...
Recently we identified multiple suramin-sensitivity genes with a genome wide screen in Trypanosoma b...
Recently we identified multiple suramin-sensitivity genes with a genome wide screen in Trypanosoma b...
AbstractAfrican sleeping sickness is a debilitating and often fatal disease caused by tsetse fly tra...
Suramin was introduced into the clinic a century ago and is still used to treat the first stage of a...
Iron is an essential element for life. Its uptake and utility requires a careful balancing with its ...
The surface proteins of parasitic protozoa mediate functions essential to survival within a host, in...
AbstractUptake of host transferrin (Tf) in Trypanosoma brucei is mediated by a heterodimeric, glycos...
African trypanosomes are highly divergent from their metazoan hosts, and as part of adaptation to a ...
To maintain prolonged infection of mammals, African trypanosomes have evolved remarkable surface coa...