Pyrrolcarboxamide derivatives for the inhbition of erk5

Chemical research in the group of hybrid pyrrolidine-2,5-dione derivatives with potential anticonvulsant and antinociceptive activity in animal models

Jakubiec, Marcin

We wstępie niniejszej pracy magisterskiej scharakteryzowano kanały potasowe z podrodziny KCNQ. W roz...

Design, synthesis and biological evaluation of pyrrole derivatives as coactivator associated arginine methyltransferase 1 (CARM1) inhibitors

CIANCIULLI, Agostino
Milite, Ciro
Castellano, Sabrina
CHINI, MARIA GIOVANNA
Bifulco, Giuseppe
Xu, Wei
Sbardella, Gianluca

January 2015

Coactivator-Associated Arginine Methyltransferase 1 (CARM1, also known as PRMT4) is involved in many...

Annellated pyrrole compounds for cancer management

July 2015

none6The present invention relates to the use of annellated pyrrole compounds and in particular ML30...

Pyrrolcarboxamide derivatives for the inhbition of ERK5

Reuillon, Tristan
Miller, Duncan
Myers, Stephanie
Molyneux, Lauren
Cano, Céline
Hardcastle, Ian
Griffin, Roger
Rigoreau, Laurent
Golding, Bernard
Noble, Martin

March 2016

The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutical...

Pyrimidinone derivatives and uses thereof to neutralize the biological activity of chemokines

Bonnet, D. (Dominique)
Frossard, N. (Nelly)
Galzi, J. (Jean-Luc)
Guignabert, C. (Christophe)
Hibert, M. (Marcel)
Simonin, F. (Frédéric)
Muller, S. (Sylviane)

January 2018

A subject of the present invention is a compound having the general formula (I) a pharmaceutically a...

4-Amino-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and their preparation, pharmaceutical composistion and use antitumor and antileukemic agents

F. BONDAVALLI
M. BOTTA
O. BRUNO
F. MANETTI
S. SCHENONE
F. CARRARO

January 2004

4-\u200bAmino-\u200bsubstituted pyrazolo[3,\u200b4-\u200bd]\u200bpyrimidine and pyrrolo[2,\u200b3-\u...

PYRROLIDINE SALTS OF N-DIMETHYLPIPERAZINO DITHIO-CARBONIC OR N-MORPHOLINODITHIOCARBOXYLIC ACID HAVING RADIOPROTECTIVE

Сидорова, Л. П.
Тарахтий, Э. А.
Расина, Л. Н.
Чупахин, О. Н.
Sidorova, L. P.
Tarakhtij, Eh. A.
Rasina, L. N.
Chupakhin, O. N.

January 1998

FIELD: medicine. SUBSTANCE: product: pyrrolidine salts of N-methylpiperazinodithiocarboxylic or N-mo...

4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer

Routier, Sylvain
Bénédetti, Hélène
Vallée, Béatrice
Bonnet, Pascal
Plé, Karen
Aci-Seche, Samia
Ruchaud, Sandrine
Braka, Abdennour
Champire, Anthony
Andres, Christian R.
Vourc'H, Patrick

December 2021

The present invention concerns a compound of formula (I), in particular as LIMK and/or ROCK kinases ...

5-(PYRIMIDIN-4-YL)-2-(PYRROLIDIN-1-YL)NICOTINONITRILE COMPOUNDS AS IKKE, TBK1 AND/OR SIK2 KINASES INHIBITORS

Newton, G

August 2018

The invention provides compounds of formula (I) wherein R is −CH3 or −CH2CH3 and pharmaceutically ac...

Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities

Gouda Ahmed M.
Abdelazeem Ahmed H.
Abdalla Ashraf N.
Ahmed Muhammad

September 2018

Towards optimization of the pyrrolizine-5-carboxamide scaffold, a novel series of six derivatives (4...

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

Tucker, Julie Ann
Myers, Stephanie M.
Miller, Duncan C.
Molyneux, Lauren
Arasta, Mercedes
Bawn, Ruth H.
Blackburn, Timothy J.
Cook, Simon J.
Edwards, Noel
Endicott, Jane A.
Golding, Bernard T.
Griffin, Roger J.
Hammonds, Tim
Hardcastle, Ian R.
Harnor, Suzannah J.
Heptinstall, Amy B.
Lochhead, Pamela A.
Martin, Mathew P.
Martin, Nick C.
Newell, David R.
Owen, Paul J.
Pang, Leon C.
Reuillon, Tristan
Rigoreau, Laurent J.M.
Thomas, Huw D.
Wang, Lan-Zhen
Wong, Ai-Ching
Noble, Martin E.M.
Wedge, Stephen R.
Cano, Celine

September 2019

Extracellular regulated kinase 5 (ERK5) signalling has been implicated in driving a number of cellul...

On the Use of 2,5-Dimethyl-Pyrrol-1-yl-Benzoic Acid Derivatives as EPH-Ephrin Antagonists

Alessio Lodola
Matteo Incerti
Massimiliano Tognolini

September 2016

Since their discovery as EPH receptor inhibitors in 2008 (1),2,5-dimethyl pyrrol-1-yl-benzoic acid d...

4-Amine-substituted derivatives of pyrazolo[3,4-d]pyrimidine and their preparation, pharmaceutical compositions, and use as antitumor agents

Bondavalli F
Botta M
Manetti F
Donnini S
Schenone S
Ziche M.

January 2004

Title compds. I [R1 = cyclopropylamino, NHPr, pyrrolidin-1-yl, NHBu, NEt2, morpholin-4-yl, NHCH2CH2O...

USE OF 2-OXO-2H-PYRROL-1(5H)-CARBOXAMIDE DERIVATIVES AS ANTI-HIV AGENTS AND PROCESS FOR THE PRODUCTION THEREOF

COSTA, Mirco
DELLA CA', Nicola

January 2017

The present pharmaceutical invention is related to the use, in the medical field, of 2-oxo-2h-pirrol...

Benzo[e]pyridoindole, the novel kinase inhibitor family with antiproliferative activity

Vu Hong, Lien

October 2011

Les Benzo[e]pyridoindoles sont identifiés comme inhibiteurs des kinases Aurora. La molécule la plus ...

Chemical research in the group of hybrid pyrrolidine-2,5-dione derivatives with potential anticonvulsant and antinociceptive activity in animal models

Jakubiec, Marcin

We wstępie niniejszej pracy magisterskiej scharakteryzowano kanały potasowe z podrodziny KCNQ. W roz...

Design, synthesis and biological evaluation of pyrrole derivatives as coactivator associated arginine methyltransferase 1 (CARM1) inhibitors

CIANCIULLI, Agostino
Milite, Ciro
Castellano, Sabrina
CHINI, MARIA GIOVANNA
Bifulco, Giuseppe
Xu, Wei
Sbardella, Gianluca

January 2015

Coactivator-Associated Arginine Methyltransferase 1 (CARM1, also known as PRMT4) is involved in many...

Annellated pyrrole compounds for cancer management

July 2015

none6The present invention relates to the use of annellated pyrrole compounds and in particular ML30...

Pyrrolcarboxamide derivatives for the inhbition of ERK5

Reuillon, Tristan
Miller, Duncan
Myers, Stephanie
Molyneux, Lauren
Cano, Céline
Hardcastle, Ian
Griffin, Roger
Rigoreau, Laurent
Golding, Bernard
Noble, Martin

March 2016

The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutical...

Pyrimidinone derivatives and uses thereof to neutralize the biological activity of chemokines

Bonnet, D. (Dominique)
Frossard, N. (Nelly)
Galzi, J. (Jean-Luc)
Guignabert, C. (Christophe)
Hibert, M. (Marcel)
Simonin, F. (Frédéric)
Muller, S. (Sylviane)

January 2018

A subject of the present invention is a compound having the general formula (I) a pharmaceutically a...

4-Amino-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and their preparation, pharmaceutical composistion and use antitumor and antileukemic agents

F. BONDAVALLI
M. BOTTA
O. BRUNO
F. MANETTI
S. SCHENONE
F. CARRARO

January 2004

4-\u200bAmino-\u200bsubstituted pyrazolo[3,\u200b4-\u200bd]\u200bpyrimidine and pyrrolo[2,\u200b3-\u...

PYRROLIDINE SALTS OF N-DIMETHYLPIPERAZINO DITHIO-CARBONIC OR N-MORPHOLINODITHIOCARBOXYLIC ACID HAVING RADIOPROTECTIVE

Сидорова, Л. П.
Тарахтий, Э. А.
Расина, Л. Н.
Чупахин, О. Н.
Sidorova, L. P.
Tarakhtij, Eh. A.
Rasina, L. N.
Chupakhin, O. N.

January 1998

FIELD: medicine. SUBSTANCE: product: pyrrolidine salts of N-methylpiperazinodithiocarboxylic or N-mo...

4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer

Routier, Sylvain
Bénédetti, Hélène
Vallée, Béatrice
Bonnet, Pascal
Plé, Karen
Aci-Seche, Samia
Ruchaud, Sandrine
Braka, Abdennour
Champire, Anthony
Andres, Christian R.
Vourc'H, Patrick

December 2021

The present invention concerns a compound of formula (I), in particular as LIMK and/or ROCK kinases ...

5-(PYRIMIDIN-4-YL)-2-(PYRROLIDIN-1-YL)NICOTINONITRILE COMPOUNDS AS IKKE, TBK1 AND/OR SIK2 KINASES INHIBITORS

Newton, G

August 2018

The invention provides compounds of formula (I) wherein R is −CH3 or −CH2CH3 and pharmaceutically ac...

Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities

Gouda Ahmed M.
Abdelazeem Ahmed H.
Abdalla Ashraf N.
Ahmed Muhammad

September 2018

Towards optimization of the pyrrolizine-5-carboxamide scaffold, a novel series of six derivatives (4...

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

Tucker, Julie Ann
Myers, Stephanie M.
Miller, Duncan C.
Molyneux, Lauren
Arasta, Mercedes
Bawn, Ruth H.
Blackburn, Timothy J.
Cook, Simon J.
Edwards, Noel
Endicott, Jane A.
Golding, Bernard T.
Griffin, Roger J.
Hammonds, Tim
Hardcastle, Ian R.
Harnor, Suzannah J.
Heptinstall, Amy B.
Lochhead, Pamela A.
Martin, Mathew P.
Martin, Nick C.
Newell, David R.
Owen, Paul J.
Pang, Leon C.
Reuillon, Tristan
Rigoreau, Laurent J.M.
Thomas, Huw D.
Wang, Lan-Zhen
Wong, Ai-Ching
Noble, Martin E.M.
Wedge, Stephen R.
Cano, Celine

September 2019

Extracellular regulated kinase 5 (ERK5) signalling has been implicated in driving a number of cellul...

On the Use of 2,5-Dimethyl-Pyrrol-1-yl-Benzoic Acid Derivatives as EPH-Ephrin Antagonists

Alessio Lodola
Matteo Incerti
Massimiliano Tognolini

September 2016

Since their discovery as EPH receptor inhibitors in 2008 (1),2,5-dimethyl pyrrol-1-yl-benzoic acid d...

4-Amine-substituted derivatives of pyrazolo[3,4-d]pyrimidine and their preparation, pharmaceutical compositions, and use as antitumor agents

Bondavalli F
Botta M
Manetti F
Donnini S
Schenone S
Ziche M.

January 2004

Title compds. I [R1 = cyclopropylamino, NHPr, pyrrolidin-1-yl, NHBu, NEt2, morpholin-4-yl, NHCH2CH2O...

USE OF 2-OXO-2H-PYRROL-1(5H)-CARBOXAMIDE DERIVATIVES AS ANTI-HIV AGENTS AND PROCESS FOR THE PRODUCTION THEREOF

COSTA, Mirco
DELLA CA', Nicola

January 2017

The present pharmaceutical invention is related to the use, in the medical field, of 2-oxo-2h-pirrol...

Benzo[e]pyridoindole, the novel kinase inhibitor family with antiproliferative activity

Vu Hong, Lien

October 2011

Les Benzo[e]pyridoindoles sont identifiés comme inhibiteurs des kinases Aurora. La molécule la plus ...

Chemical research in the group of hybrid pyrrolidine-2,5-dione derivatives with potential anticonvulsant and antinociceptive activity in animal models

Jakubiec, Marcin

We wstępie niniejszej pracy magisterskiej scharakteryzowano kanały potasowe z podrodziny KCNQ. W roz...

Design, synthesis and biological evaluation of pyrrole derivatives as coactivator associated arginine methyltransferase 1 (CARM1) inhibitors

CIANCIULLI, Agostino
Milite, Ciro
Castellano, Sabrina
CHINI, MARIA GIOVANNA
Bifulco, Giuseppe
Xu, Wei
Sbardella, Gianluca

January 2015

Coactivator-Associated Arginine Methyltransferase 1 (CARM1, also known as PRMT4) is involved in many...

Annellated pyrrole compounds for cancer management

July 2015

none6The present invention relates to the use of annellated pyrrole compounds and in particular ML30...

Pyrrolcarboxamide derivatives for the inhbition of erk5

Abstract

Extracted data

Pyrrolcarboxamide derivatives for the inhbition of erk5

Abstract

Extracted data

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