Data generation methods differ across the empirical sciences. Today’s physicists and engineers primarily generate data with automated technologies. Behavioural, psychological and social scientists explore phenomena that are not technically accessible (e.g., attitudes, social beliefs) or only in limited ways (e.g., behaviours) and therefore generate data primarily with persons. But human abilities are involved in any data generation, even when technologies are used and developed. This article explores concepts and methods of data generation of different sciences from transdisciplinary and philosophy-of-science perspectives. It highlights that empirical data can reveal information about the phenomena under study only if relevant properties of...