Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, stimulator of interferon genes (STING) encoded by Tmem173. In this study, we demonstrate that STING triggers adaptive immune responses that control Th17 differentiation. Cyclic dinucleotides recognition enables classical dendritic cells (cDCs) that predominantly express CD103 to induce Th17 lymphocytes in an IL-6/IL-1β-dependent manner in gut. STING expression in human lamina propria is associated with the severity of mucosal inflammation and clinical disease activity in patients with Crohn’s disease. Mice deficient in Tmem173 fail to mount Th17 responses to cyclic dinucleotides or prevent immune evasion of enteroinvasive pathogens. In summary, ST...
Infection with Listeria monocytogenes strains that enter the host cell cytosol leads to a robust cyt...
SummaryHow the development of antibacterial T helper 17 (Th17) cells is selectively promoted by anti...
Few current vaccines can establish antigen (Ag)-specific immune responses in both mucosal and system...
<p>Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, st...
<p>Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, st...
<p>Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, st...
<p>Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, st...
<p>Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, st...
The innate immune system detects infection by employing germline-encoded receptors specific for cons...
The innate immune system detects infection by using germline-encoded receptors that are specific for...
Initial skirmishes between the host and pathogen result in spillage of the contents of the bacterial...
STING, stimulator of interferon genes, is an innate immune sensor of cyclic dinucleotides that regul...
The early detection of bacterial pathogens through immune sensors is an essential step in innate imm...
Stimulator of interferon genes (STING) acts as a cytoplasmic signaling hub of innate immunity that i...
SummaryHow commensal microbiota contributes to immune cell homeostasis at barrier surfaces is poorly...
Infection with Listeria monocytogenes strains that enter the host cell cytosol leads to a robust cyt...
SummaryHow the development of antibacterial T helper 17 (Th17) cells is selectively promoted by anti...
Few current vaccines can establish antigen (Ag)-specific immune responses in both mucosal and system...
<p>Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, st...
<p>Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, st...
<p>Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, st...
<p>Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, st...
<p>Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, st...
The innate immune system detects infection by employing germline-encoded receptors specific for cons...
The innate immune system detects infection by using germline-encoded receptors that are specific for...
Initial skirmishes between the host and pathogen result in spillage of the contents of the bacterial...
STING, stimulator of interferon genes, is an innate immune sensor of cyclic dinucleotides that regul...
The early detection of bacterial pathogens through immune sensors is an essential step in innate imm...
Stimulator of interferon genes (STING) acts as a cytoplasmic signaling hub of innate immunity that i...
SummaryHow commensal microbiota contributes to immune cell homeostasis at barrier surfaces is poorly...
Infection with Listeria monocytogenes strains that enter the host cell cytosol leads to a robust cyt...
SummaryHow the development of antibacterial T helper 17 (Th17) cells is selectively promoted by anti...
Few current vaccines can establish antigen (Ag)-specific immune responses in both mucosal and system...