The forces driving the accumulation and removal of non-coding DNA and ultimately the evolution of genome size in complex organisms are intimately linked to genome structure and organisation. Our analysis provides a novel method for capturing the regional variation of lineage-specific DNA gain and loss events in their respective genomic contexts. To further understand this connection we used comparative genomics to identify genome-wide individual DNA gain and loss events in the human and mouse genomes. Focusing on the distribution of DNA gains and losses, relationships to important structural features and potential impact on biological processes, we found that in autosomes, DNA gains and losses both followed separate lineage-specific accumul...
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the prem...
Chromosomal evolution involves multiple changes at structural and numerical levels. These changes, w...
AbstractBackground: Nucleotide substitution rates and G + C content vary considerably among mammalia...
<div><p>The forces driving the accumulation and removal of non-coding DNA and ultimately the evoluti...
Abstract Background With the completion of the whole genome sequence for many organisms, investigati...
<div><p>Several recent studies have examined different aspects of mammalian higher order chromatin s...
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the prem...
To study the evolutionary dynamics of regulatory DNA, we mapped >1.3 million deoxyribonuclease I-hyp...
<p>Levels of DNA turnover reflect the rate of DNA gain or loss that can be attributed to each branch...
Summary As the premier model organism in biomedical research, the laboratory mouse shares the majori...
Several recent studies have examined different aspects of mammalian higher order chromatin structure...
Conserved non-protein-coding DNA elements (CNEs) often encode cis-regulatory elements and are rarely...
Retrotransposons comprise a large portion of mammalian genomes. They contribute to structural change...
Although analysis of genome rearrangements was pioneered by Dobzhansky and Sturtevant 65 years ago, ...
Retrotransposons comprise a large portion ofmammalian genomes. They contribute to structural changes...
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the prem...
Chromosomal evolution involves multiple changes at structural and numerical levels. These changes, w...
AbstractBackground: Nucleotide substitution rates and G + C content vary considerably among mammalia...
<div><p>The forces driving the accumulation and removal of non-coding DNA and ultimately the evoluti...
Abstract Background With the completion of the whole genome sequence for many organisms, investigati...
<div><p>Several recent studies have examined different aspects of mammalian higher order chromatin s...
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the prem...
To study the evolutionary dynamics of regulatory DNA, we mapped >1.3 million deoxyribonuclease I-hyp...
<p>Levels of DNA turnover reflect the rate of DNA gain or loss that can be attributed to each branch...
Summary As the premier model organism in biomedical research, the laboratory mouse shares the majori...
Several recent studies have examined different aspects of mammalian higher order chromatin structure...
Conserved non-protein-coding DNA elements (CNEs) often encode cis-regulatory elements and are rarely...
Retrotransposons comprise a large portion of mammalian genomes. They contribute to structural change...
Although analysis of genome rearrangements was pioneered by Dobzhansky and Sturtevant 65 years ago, ...
Retrotransposons comprise a large portion ofmammalian genomes. They contribute to structural changes...
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the prem...
Chromosomal evolution involves multiple changes at structural and numerical levels. These changes, w...
AbstractBackground: Nucleotide substitution rates and G + C content vary considerably among mammalia...