[[abstract]]Although metabolic reprogramming is recognized as a hallmark of tumorigenesis and progression, little is known about metabolic enzymes and oncometabolites that regulate breast cancer metastasis, and very few metabolic molecules have been identified as potential therapeutic targets. In this study, the transketolase (TKT) expression correlated with tumor size in the 4T1/BALB/c syngeneic model. In addition, TKT expression was higher in lymph node metastases compared with primary tumor or normal tissues of patients, and high TKT levels were associated with poor survival. Depletion of TKT or addition of alpha-ketoglutarate (alpha-KG) enhanced the levels of tumor suppressors succinate dehydrogenase (SDH) and fumarate hydratase (FH), d...
Aim: Malignant tumours ferment glucose to lactate even in the presence of sufficient oxygen (the War...
Background: Canine mammary tumors represent the most common neoplasm in female dogs, and the discove...
Published online: 21 April 2015Ovarian cancer, the most lethal gynaecological cancer, is characteris...
[[abstract]]Although metabolic reprogramming is recognized as a hallmark of tumorigenesis and progre...
Cancer cells experience an increase in oxidative stress. The pentose phosphate pathway (PPP) is a ma...
Metabolic reprogramming, a crucial cancer hallmark, shifts metabolic pathways such as glycolysis, tr...
Abstract Tumours ferment glucose to lactate even in the presence of oxygen (aerobic glycolysis; War...
Abstract Background Metabolic reprogramming is one of the hallmarks of cancer cells. The pentose pho...
[[abstract]]Up-regulation of hypoxia-inducible factor-1alpha (HIF-1alpha), even in normoxia, is a co...
Tumours ferment glucose to lactate even in the presence of oxygen (aerobic glycolysis; Warburg effec...
The thriving field that constitutes cancer metabolism has unveiled some groundbreaking facts over th...
The pentose phosphate pathway is a fundamental metabolic pathway that provides cells with ribose and...
Background: Transketolase-like 1 (TKTL1) induces glucose degradation through anaerobic pathways, eve...
Despite the development of metabolism-based therapy for a variety of malignancies, resistance to sin...
Background Transketolase-like 1 (TKTL1) induces glucose degradation through anaerobic pathways, even...
Aim: Malignant tumours ferment glucose to lactate even in the presence of sufficient oxygen (the War...
Background: Canine mammary tumors represent the most common neoplasm in female dogs, and the discove...
Published online: 21 April 2015Ovarian cancer, the most lethal gynaecological cancer, is characteris...
[[abstract]]Although metabolic reprogramming is recognized as a hallmark of tumorigenesis and progre...
Cancer cells experience an increase in oxidative stress. The pentose phosphate pathway (PPP) is a ma...
Metabolic reprogramming, a crucial cancer hallmark, shifts metabolic pathways such as glycolysis, tr...
Abstract Tumours ferment glucose to lactate even in the presence of oxygen (aerobic glycolysis; War...
Abstract Background Metabolic reprogramming is one of the hallmarks of cancer cells. The pentose pho...
[[abstract]]Up-regulation of hypoxia-inducible factor-1alpha (HIF-1alpha), even in normoxia, is a co...
Tumours ferment glucose to lactate even in the presence of oxygen (aerobic glycolysis; Warburg effec...
The thriving field that constitutes cancer metabolism has unveiled some groundbreaking facts over th...
The pentose phosphate pathway is a fundamental metabolic pathway that provides cells with ribose and...
Background: Transketolase-like 1 (TKTL1) induces glucose degradation through anaerobic pathways, eve...
Despite the development of metabolism-based therapy for a variety of malignancies, resistance to sin...
Background Transketolase-like 1 (TKTL1) induces glucose degradation through anaerobic pathways, even...
Aim: Malignant tumours ferment glucose to lactate even in the presence of sufficient oxygen (the War...
Background: Canine mammary tumors represent the most common neoplasm in female dogs, and the discove...
Published online: 21 April 2015Ovarian cancer, the most lethal gynaecological cancer, is characteris...