Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania
- Makani, Julie
- Mgaya, Josephine
- Balandya, Emmanuel
- Msami, Khadija
- Soka, Deogratias
- Cox, Sharon E.
- Komba, Albert N
- Rwezaula, Stella
- Meda, Elineema
- Muturi, David
- Kitundu, Jesse
- Fegan, Gregory
- Kirkham, Fenella J.
- Newton, Charles R
- Snow, Robert W
- Lowe, Brett
DOIAbstract
Bacteraemia is a leading cause of morbidity in sickle cell anaemia (SCA), but information from studies in Africa is limited. We evaluated 890 admissions from 648 SCA patients at a tertiary hospital in Tanzania. Bacteraemia was present in 43 admissions (4·8%); isolates included Staphylococcus aureus (12/43; 28%), non-Typhi Salmonella (9/43; 21%), Streptococcus pneumoniae (3/43; 7%) and Salmonella Typhi (2/43; 5%). Compared to SCA patients without bacteraemia, SCA patients with bacteraemia had significantly lower haemoglobin [71 g/l vs. 62 g/l, odds ratio 0·72 (95% confidence interval 0·56-0·91), P < 0·01]. Further exploration is needed of the relationship between anaemia and bacterial infections in SCA in Africa.</p
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