Relationship between hippocampal volume and frequency of event retrieval using the historic events memory test in people with Alzheimer's disease

Core symptom in Alzheimer's disease (AD) is a retrograde amnesia, where recent events are often significantly more affected than remote events. The hippocampus which is considered as a crucial neuroanatomical structure for memory consolidation is early impaired in this neurodegenerative disease. In the standard model of consolidation it is assumed that this temporal gradient in memory performance is due to a time-limited role of the hippocampus in memory storage. Remote events become stored in the neocortex and are therefore not affected by the hippocampal damage