Add to ORKGIn this multimodal, double-blind, randomized, placebo-controlled PET-MRS study in 20 healthy subjects, we report a pharmacological modulation of glutamate-dependent neuroreceptor plasticity in the pregenual anterior cingulate cortex following the administration of the NMDA-receptor antagonist ketamine. In order to investigate the functional interplay between the major excitatory neurotransmitter glutamate (Glu) and the density of the metabotropic glutamate receptor subtype 5 (mGluR5) we combined proton magnetic resonance spectroscopy (1H-MRS) with positron emission tomography (11C-ABP688-PET). Our findings complement previous reports of increased glutamate release during ketamine challenge by providing additional in vivo molecular imaging e...
Ketamine exerts its rapid antidepressant effects via modulation of the glutamatergic system. While n...
Ketamine is a non-competitive antagonist of the NMDA glutamate receptor with psychotomimetic and rei...
Increased amygdala reactivity might lead to negative bias during emotional processing that can be re...
Introduction Information processing in the brain relies on the release and diffusion of neurotransmi...
Objective Based on the growing evidence for imbalance with regard to glutamatergic (Glu) neurotransm...
Background: Recent findings highlight the role of glutamate-driven synaptic plasticity in the therap...
Background: Ketamine is a potent NMDA receptor antagonist with rapid antidepressant properties at su...
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at ...
Ketamine is a powerful glutamatergic long-lasting antidepressant, efficient in intractable major dep...
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties, th...
A growing body of literature has demonstrated the potential for ketamine in the treatment of major d...
Ketamine, an NMDA receptor antagonist, is increasingly used to study the link between glutamatergic ...
Introduction: Converging evidence suggests that ketamine elicits antidepressant effects via enhance...
Glutamate is the most abundant excitatory neurotransmitter in the human brain, but in vivo imaging o...
Background / Purpose: Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidep...
Ketamine exerts its rapid antidepressant effects via modulation of the glutamatergic system. While n...
Ketamine is a non-competitive antagonist of the NMDA glutamate receptor with psychotomimetic and rei...
Increased amygdala reactivity might lead to negative bias during emotional processing that can be re...
Introduction Information processing in the brain relies on the release and diffusion of neurotransmi...
Objective Based on the growing evidence for imbalance with regard to glutamatergic (Glu) neurotransm...
Background: Recent findings highlight the role of glutamate-driven synaptic plasticity in the therap...
Background: Ketamine is a potent NMDA receptor antagonist with rapid antidepressant properties at su...
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at ...
Ketamine is a powerful glutamatergic long-lasting antidepressant, efficient in intractable major dep...
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties, th...
A growing body of literature has demonstrated the potential for ketamine in the treatment of major d...
Ketamine, an NMDA receptor antagonist, is increasingly used to study the link between glutamatergic ...
Introduction: Converging evidence suggests that ketamine elicits antidepressant effects via enhance...
Glutamate is the most abundant excitatory neurotransmitter in the human brain, but in vivo imaging o...
Background / Purpose: Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidep...
Ketamine exerts its rapid antidepressant effects via modulation of the glutamatergic system. While n...
Ketamine is a non-competitive antagonist of the NMDA glutamate receptor with psychotomimetic and rei...
Increased amygdala reactivity might lead to negative bias during emotional processing that can be re...