4'-ethyl-7-phenylsulfonylgenistein (EPG, 3), a potential prodrug for genistein (1), was synthesized in high yield and its crystal structure was reported firstly. It possesses better physical and chemical properties such as solubility, lipid/water partition coefficient, LogP, and hydrolysis kinetics than its original form. The LogP value (2.07) and the half-life of the hydrolysis value (13.4 h) show that its oral bioavailability is possibly improved evidently compared with that of genistein. These results indicate that EPG can be considered a potential prodrug for genistein.Colegio de Farmacéuticos de la Provincia de Buenos Aire
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Paclitaxel (PTX) is a famous anti-cancer drug with poor aqueous solubility. In clinical practices, C...
Soy isoflavones have been extensively studied because of their possible benefits to human health. Ge...
Most medicines are coming with toxic and detrimental side effects. In addition, microbials are resis...
Oral administration is the most preferred route of drug intake. But it is not suitable for many drug...
7-Enthyl-4’-phenylsulfonyldaidzein (EPD 3), a potential prodrug for daidzein, was synthesized in hig...
The oral bioavailability of genistein (GE) in its benzensulfonates was studied in search for new dru...
Research has indicated the health beneficial effects of soyfoods. Genistein, one of the primary bioa...
AbstractGenistein (GEN), an isoflavonoid, offers multifunctional biological activities. However, its...
Genistein is an isoflavone first isolated from the brooming plant Dyer\u27s Genista tinctoria L. and...
The project aimed to synthesize new prodrugs of bioactive molecules and new self-assembling fully bi...
The objective of this study is to improve and optimize the formulation of Genistein in capsules in o...
We describe here three urea-based soluble epoxide hydrolase (sEH) inhibitors from the root of the pl...
Peptide and protein biologics are therapeutics and prophylactics known for their desirability of hig...
Abstract: An efficient method of thiol group introduction to the structure of common natural product...
Summary: The purpose of this study was to analyze molecular docking as a search for aglycone isoflav...
Paclitaxel (PTX) is a famous anti-cancer drug with poor aqueous solubility. In clinical practices, C...
Soy isoflavones have been extensively studied because of their possible benefits to human health. Ge...
Most medicines are coming with toxic and detrimental side effects. In addition, microbials are resis...
Oral administration is the most preferred route of drug intake. But it is not suitable for many drug...
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