Immunosuppression is a typical hallmark of cancer and frequently includes perturbations of the NKG2D tumor recognition system as well as impaired signaling by other activating NK cell receptors. Several in vitro studies suggested that sustained engagement of the NKG2D receptor, as it is occurring in the tumor microenvironment, not only impairs expression and function of NKG2D but also impacts signaling by other activating NK receptors. Here, we made use of a transgenic mouse model of ubiquitous NKG2D ligand expression (H2-Kb-MICA mice) to investigate consequences of chronic NKG2D engagement in vivo for functional responsiveness by other activating NK receptors such as NKp46 and Ly49D. Unexpectedly, we found no evidence for an impairment of ...
Little is known on the control of lymphomas by NK cells. Here, we study the role of the NK group 2D ...
In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular a...
Natural Killer (NK) cells are crucial effectors of the immune response to tumors and infections. NK ...
Immunosuppression is a typical hallmark of cancer and frequently includes perturbations of the NKG2D...
NKG2D is an activation receptor that allows natural killer (NK) cells to detect diseased host cells....
International audienceNKG2D is a multisubunit activation receptor that allows natural killer (NK) ce...
NKG2D is a receptor on natural killer (NK) cells and cytotoxic T lymphocytes that binds major histoc...
NK cells are innate lymphocytes responsible for lysis of pathogen-infected and transformed cells. On...
AbstractNonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus, have a defect ...
Nonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus, have a defect in natur...
Nonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus, have a defect in natur...
SummaryNKG2D is a potent activating receptor on natural killer (NK) cells and acts as a molecular se...
It is now clear that recognition of nascent tumors by the immune system is critical for survival of ...
NKG2D and natural cytotoxicity receptors (NCR) are essential recognition structures that mediate NK ...
NKG2D is an activating receptor that is mostly expressed on cells of the cytotoxic arm of the immune...
Little is known on the control of lymphomas by NK cells. Here, we study the role of the NK group 2D ...
In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular a...
Natural Killer (NK) cells are crucial effectors of the immune response to tumors and infections. NK ...
Immunosuppression is a typical hallmark of cancer and frequently includes perturbations of the NKG2D...
NKG2D is an activation receptor that allows natural killer (NK) cells to detect diseased host cells....
International audienceNKG2D is a multisubunit activation receptor that allows natural killer (NK) ce...
NKG2D is a receptor on natural killer (NK) cells and cytotoxic T lymphocytes that binds major histoc...
NK cells are innate lymphocytes responsible for lysis of pathogen-infected and transformed cells. On...
AbstractNonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus, have a defect ...
Nonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus, have a defect in natur...
Nonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus, have a defect in natur...
SummaryNKG2D is a potent activating receptor on natural killer (NK) cells and acts as a molecular se...
It is now clear that recognition of nascent tumors by the immune system is critical for survival of ...
NKG2D and natural cytotoxicity receptors (NCR) are essential recognition structures that mediate NK ...
NKG2D is an activating receptor that is mostly expressed on cells of the cytotoxic arm of the immune...
Little is known on the control of lymphomas by NK cells. Here, we study the role of the NK group 2D ...
In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular a...
Natural Killer (NK) cells are crucial effectors of the immune response to tumors and infections. NK ...