The sensitive detection of circulating tumour cells in patients with differentiated thyroid cancer may precede the detection of relapse by other diagnostic studies – such as serum thyroglobulin – and thus may have important therapeutic and prognostic implications. We performed reverse transcription-polymerase chain reaction (RT-PCR) on blood samples from patients diagnosed with thyroid disease using two different RT-PCR sensitivities. Additionally, tissue specificity of TG mRNA-expression was determined using RNA extracts from 27 different human tissues. The lower limit of detection was 50–100 TG mRNA producing cells/ml blood using a ‘normal’ RT-PCR sensitivity and 10–20 cells/ml blood using a ‘high’ sensitivity. With the normal sensitivity...
Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its incidence has increa...
OBJECTIVE: The TSH receptor (TSHr) expressed on thyroid follicular cells is the autoantigen involve...
Titelblatt und Inhaltsverzeichnis Einleitung Material und Methoden Ergebnisse Diskussion L...
Aims: Monitoring treated patients with thyroid cancer for recurrent or metastatic disease is current...
Thyroid carcinoma (TC) comprises a spectrum of different tumors with a wide range of biological beha...
BACKGROUND: As recurrences after treatment for differentiated thyroid cancer can occur many years af...
To investigate whether circulating thyroglobulin (Tg) messenger ribonucleic acid (mRNA) and sodium/i...
BACKGROUND: The prognostic significance of molecular staging using thyroglobulin (Tg)-based RT-PCR a...
AbstractThyroid cancer is the most prevalent endocrine malignancy. The preoperative diagnosis of dif...
We studied the potential role of innovative diagnostic tools for the management of patients with dif...
BACKGROUND: The objective of the current study was to evaluate the ability of serum thyroglobulin mR...
BACKGROUND: The aim of the present study was to evaluate if serum Tg mRNA assay predicts recurrenc...
Thyroid cancer is the most prevalent endocrine malignancy. The preoperative diagnosis of differentia...
BackgroundThe standard of care for thyroid cancer management is thyroidectomy and adjuvant radioacti...
We report a PCR-based technique for detecting thyroid cancer metastases in small nodes <1.5 cm diame...
Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its incidence has increa...
OBJECTIVE: The TSH receptor (TSHr) expressed on thyroid follicular cells is the autoantigen involve...
Titelblatt und Inhaltsverzeichnis Einleitung Material und Methoden Ergebnisse Diskussion L...
Aims: Monitoring treated patients with thyroid cancer for recurrent or metastatic disease is current...
Thyroid carcinoma (TC) comprises a spectrum of different tumors with a wide range of biological beha...
BACKGROUND: As recurrences after treatment for differentiated thyroid cancer can occur many years af...
To investigate whether circulating thyroglobulin (Tg) messenger ribonucleic acid (mRNA) and sodium/i...
BACKGROUND: The prognostic significance of molecular staging using thyroglobulin (Tg)-based RT-PCR a...
AbstractThyroid cancer is the most prevalent endocrine malignancy. The preoperative diagnosis of dif...
We studied the potential role of innovative diagnostic tools for the management of patients with dif...
BACKGROUND: The objective of the current study was to evaluate the ability of serum thyroglobulin mR...
BACKGROUND: The aim of the present study was to evaluate if serum Tg mRNA assay predicts recurrenc...
Thyroid cancer is the most prevalent endocrine malignancy. The preoperative diagnosis of differentia...
BackgroundThe standard of care for thyroid cancer management is thyroidectomy and adjuvant radioacti...
We report a PCR-based technique for detecting thyroid cancer metastases in small nodes <1.5 cm diame...
Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its incidence has increa...
OBJECTIVE: The TSH receptor (TSHr) expressed on thyroid follicular cells is the autoantigen involve...
Titelblatt und Inhaltsverzeichnis Einleitung Material und Methoden Ergebnisse Diskussion L...