Amino acid alignment of the <i>F</i>. <i>hepatica</i> taurine transporter (Fh TauT) with the human serotonin transporter (Hs SERT), the GABA-transporter-2 of <i>C</i>. <i>sinensis</i> (Cs GAT2), the human GABA-transporter-2 (Hs GAT2) and the human taurine transporter (Hs TauT).

<p>Amino acids are represented in their single-letter code. Invariant sequences are denoted by white letters boxed in red, sequences with conservative substitutions are denoted by red letters. The red and blue arrow heads mark amino acids contributing to the first and second Na⁺ binding sites, respectively, in the crystal structure of Hs SERT. The green arrow heads highlight residues involved in the coordination of Cl^- in SERT. The cysteine residues in the second extracellular loop, which form a putative disulfide bridge, are indicated by magenta arrow heads. The brown arrow heads indicate candidate sites for N-linked glycosylation predicted by NetNGlyc 1.0 (<a href="http://www.cbs.dtu.dk/services/NetNGlyc/" target="_blank">http://www.cbs.dtu.dk/services/NetNGlyc/</a>).