HLA-A*02 allele and HLA-E genotype influence the development of HLA-E_UL40-specific CD8 T cells in HCMV⁺ individuals.

<p>(A) HLA-A*02 allele frequency and (B) genotype distribution were investigated in HCMV^- (n = 39) <i>versus</i> HCMV⁺ (n = 105) individuals including a total of 144 healthy volunteers and kidney transplant recipients (left panels) and in HCMV⁺ host with (+, n = 31) or without (-, n = 74) HLA-E_UL40 CD8 T-cell response (right panels). (C) HLA-E*01:01 and HLA-E*01:03 allele frequency and (D) HLA-E genotype distribution were investigated in HCMV^- (n = 35) <i>versus</i> HCMV⁺ (n = 96) individuals of the cohort (left panels) and in HCMV⁺ host with (+, n = 30) or without (-, n = 66) HLA-E_UL40 CD8 T-cell response (right panels). <i>P</i> values were calculated using appropriate statistical tests: Fisher’s exact test for allele frequencies and Chi-square test for genotype distribution analysis.