Metal cofactor modulated folding and target recognition of HIV-1 NCp7 - Fig 8

<p>(<b>A</b>, <b>B</b>) Free energy profiles by umbrella sampling projected onto the conformational space formed by <i>Q</i>_ZF1−SL3 and <i>Q</i>_<i>ZF</i>1 without Zn²⁺(<b>A</b>) and with saturated zinc concentration (<b>B</b>). (<b>C</b>, <b>D</b>) Same as (<b>A</b>, <b>B</b>) but projected onto the conformational space formed by <i>Q</i>_ZF2−SL3 and <i>Q</i>_<i>ZF</i>2. (<b>E</b>) Free energy profiles projected onto the conformational space formed by <i>Q</i>_ZF1−SL3 and the zinc binding energy of the ZF1. (<b>F</b>) Free energy profiles projected onto the conformational space formed by <i>Q</i>_ZF2−SL3 and the zinc binding energy of the ZF2.