Metal cofactor modulated folding and target recognition of HIV-1 NCp7 - Fig 4

<p>(<b>A</b>) Free energy surface of NCp7 projected on <i>Q</i>_<i>ZF</i>1 and <i>Q</i>_<i>ZF</i>2 at intermediate concentration of Zn²⁺. (<b>B</b>) One-dimensional free energy profiles projected onto the <i>Q</i> value of the ZF2 with the ZF1 well-folded (red) and unstructured (blue), respectively at intermediate zinc concentration. For comparison, the corresponding free energy profiles from the simulations. ‘U’ and ‘F’ denote the unfold and fold states of the ZF1, respectively. with the inter-domain interactions removed are also shown (dots).