Comparison of bacterial population dynamics under a variety of treatment regimes.

<p>The total number of bacteria, <i>B</i>_<i>T</i>(<i>t</i>) (= <i>VB</i>_<i>F</i>(<i>t</i>) + <i>A</i>_<i>r</i><i>B</i>_<i>B</i>(<i>t</i>)), is plotted in each case. Simulations extend beyond the time span of the experiments, to 2000 hours ≈ 83 days. The untreated and single inhibitor dose (‘Inhib.’) scenarios are identical to those in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006071#pcbi.1006071.g005" target="_blank">Fig 5</a>. See Treatment scenarios for a description of each treatment strategy. Case A: all treatments except single and regular inhibitor (‘Reg. Inhib.’) doses eradicate the bacterial population (such that <i>B</i>_<i>T</i>(<i>t</i>) < 1); Case B: regular inhibitor doses with regular debridement (‘Reg. Inhib. and Reg. Deb.’) and a single inhibitor dose with continuous debridement (‘Inhib. and Cont. Deb.’) are most effective, reducing the bacterial population size by an order of magnitude or more; Case C: only treatments involving continuous debridement (‘Cont. Deb.’ and ‘Inhib. and Cont. Deb.’) are effective, reducing the bacterial population size by an order of magnitude or more; Case D: no treatment strategy is effective. Eqs <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006071#pcbi.1006071.e002" target="_blank">1</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006071#pcbi.1006071.e016" target="_blank">8</a> were solved using ode15s. See Tables <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006071#pcbi.1006071.t001" target="_blank">1</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006071#pcbi.1006071.t002" target="_blank">2</a> for parameter values.