Comparison of bacterial population dynamics in the untreated and single inhibitor dose scenarios.

<p>The total number of bacteria, <i>B</i>_<i>T</i>(<i>t</i>) (= <i>VB</i>_<i>F</i>(<i>t</i>) + <i>A</i>_<i>r</i><i>B</i>_<i>B</i>(<i>t</i>)), is plotted in each case. Simulations extend beyond the time span of the experiments, to 3000 hours = 125 days. Case A: the bacterial population size is an essentially monotone increasing function of time in both untreated and treated scenarios, reaching an early steady-state at which the bacterial population size with treatment is roughly half that without; Case B: the bacterial population size with treatment remains below that without treatment, decreasing gradually after reaching an early maximum; Case C: treatment results in a sustained and significant increase in the bacterial population size, Case D: treatment causes the bacterial population size to temporarily exceed that without treatment, settling to a steady-state close to that of the untreated scenario. Eqs <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006071#pcbi.1006071.e002" target="_blank">1</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006071#pcbi.1006071.e016" target="_blank">8</a> were solved using ode15s. See Tables <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006071#pcbi.1006071.t001" target="_blank">1</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006071#pcbi.1006071.t002" target="_blank">2</a> for parameter values.