Therapeutic and protective efficacy of a dengue antibody against Zika infection in Rhesus monkeys
- Abbink, P
- Larocca, RA
- Dejnirattisai, W
- Peterson, R
- Nkolola, JP
- Borducchi, EN
- Supasa, P
- Mongkolsapaya, J
- Screaton, GR
- Barouch, DH
Publication date
March 2018
DOI Publisher
Springer Science and Business Media LLC ISSN
1078-8956 Journal
Nature MedicineAbstract
Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV) endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potent ly cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV
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