The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer
- Erstad, Derek J.
- Tager, Andrew M.
- Hoshida, Yujin
- Fuchs, Bryan C.
DOIAbstract
ABSTRACT Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC
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