Antimicrobial activity of polyphenols extracted from winery by-products against antibiotic resistant bacteria

The emergence of dmg resistant bacteria worldwide is becoming a threat to human health since commonly used antibiotics are no longer effective against these bacteria. Therefore, it is necessary to investigate and develop new effective antimicrobials. Polyphenols are secondary metabolites of plants which confer health protective benefits. Several studies have demonstrated the antimicrobial activity of these compounds since they cause structural or functional damage to the bacterial cell membrane. Agro-industrial byproducts, namely from the winey industry, are a potential source of polyphenols and can be used as cheap source of these compounds. Thus, the aim of this study was to extract the polyphenols from the winery by-products and evaluate their antimicrobial activity against antibiotic re sistant bacteria.