Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA
- Masud, Mostafa Kamal
- Islam, Md. Nazmul
- Haque, Md. Hakimul
- Tanaka, Shunsuke
- Gopalan, Vinod
- Alici, Gursel
- Nguyen, Nam-Trung
- Lam, Alfred K.
- Hossain, Md. Shahriar A.
- Yamauchi, Yusuke
- Shiddiky, Muhammad J. A.
Publication date
July 2017
DOI Publisher
Royal Society of Chemistry (RSC) ISSN
1359-7345Abstract
This paper reports the development of a nonenzymatic, amplificationfree, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC)
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