The temporal and spatial expression of three immediate early genes was investigated at the level of both mRNA and protein in the brains of rats undergoing ethanol withdrawal. Animals were made dependent by chronic vapor inhalation. All animals showed behavioral signs of withdrawal between 8 and 17 h after removal from ethanol vapor. A large, transient increase in the expression of whole brain c-fos, c-jun, and zif/268 mRNA was observed 12 h after withdrawal, and expression of their protein products was detected 15 to 24 h after withdrawal. Spatial variation in the expression of each protein was detected. All three proteins were present in the cerebral cortex, the olfactory bulb, the inferior colliculus, the granular cell layer of the cerebe...
The technique of polymerase chain reaction (PCR) differential display was used to detect alterations...
This study focused on the DNA-binding activity and protein expression of the transcription factors E...
Alcohol dependence is associated with adverse consequences of alcohol (ethanol) use and is evident i...
The expression of the proteins (C-FOS and C-JUN) encoded by the immediate early genes c-fos and c-ju...
The DNA-binding activities of AP-1 and Egr proteins were investigated in nuclear extracts of rat bra...
The DNA-binding activity of the transcription factors AP-1, CREB and OCT was investigated in nuclear...
The expression of immediate early genes (IEG)s c-fos, c-jun and zif/268 was studied during naloxone-...
textAlcoholism is a chronic, progressive and heritable disease that affects millions of Americans a...
BACKGROUND: Chronic alcohol exposure produces neuroadaptation, which increases the risk of cellular ...
Repeated ethanol exposure and withdrawal in mice increases voluntary drinking and represents an anim...
Chronic ethanol exposure and subsequent withdrawal are known to change NMDA receptor activity. This ...
International audienceBACKGROUND: Ethanol addiction has been conceptualized as a progression from oc...
Long lasting abusive consumption, dependence, and withdrawal are characteristic features of alcohol ...
<div><p>Long lasting abusive consumption, dependence, and withdrawal are characteristic features of ...
<div><p>Repeated ethanol exposure and withdrawal in mice increases voluntary drinking and represents...
The technique of polymerase chain reaction (PCR) differential display was used to detect alterations...
This study focused on the DNA-binding activity and protein expression of the transcription factors E...
Alcohol dependence is associated with adverse consequences of alcohol (ethanol) use and is evident i...
The expression of the proteins (C-FOS and C-JUN) encoded by the immediate early genes c-fos and c-ju...
The DNA-binding activities of AP-1 and Egr proteins were investigated in nuclear extracts of rat bra...
The DNA-binding activity of the transcription factors AP-1, CREB and OCT was investigated in nuclear...
The expression of immediate early genes (IEG)s c-fos, c-jun and zif/268 was studied during naloxone-...
textAlcoholism is a chronic, progressive and heritable disease that affects millions of Americans a...
BACKGROUND: Chronic alcohol exposure produces neuroadaptation, which increases the risk of cellular ...
Repeated ethanol exposure and withdrawal in mice increases voluntary drinking and represents an anim...
Chronic ethanol exposure and subsequent withdrawal are known to change NMDA receptor activity. This ...
International audienceBACKGROUND: Ethanol addiction has been conceptualized as a progression from oc...
Long lasting abusive consumption, dependence, and withdrawal are characteristic features of alcohol ...
<div><p>Long lasting abusive consumption, dependence, and withdrawal are characteristic features of ...
<div><p>Repeated ethanol exposure and withdrawal in mice increases voluntary drinking and represents...
The technique of polymerase chain reaction (PCR) differential display was used to detect alterations...
This study focused on the DNA-binding activity and protein expression of the transcription factors E...
Alcohol dependence is associated with adverse consequences of alcohol (ethanol) use and is evident i...