Chiral metallocomplex synthons of α-amino acids. Synthesis, physical-chemical properties and applications

CONCLUSIONS Study of chiral amino acids synthons resulted in: I a deeper understanding of the intramolecular interactions affecting the stereochemistry of alkylation of the metallocomplex o_amino acids synthons. The interactions are a valuable tool for evaluation of the stereochemistry of the complexes; the disclosure of new phenomena in NMR spectroscopy (unexpected long-range couphngs.); 3 synthesis ofthe stereospecific synthon ofglycine; 4 the continuing development of diagnostic tools for the clinical diagnostic of some tumours. 5 the development of an envrronmentally_friendly procedure for multikilogram-scale preparatlon of starting metallocomplex chiral synthons ofo_amino acids