Boolean network model of the fission-yeast cell-cycle.

<p>(A) A network of 9 linear threshold elements connected by excitatory (black) and inhibitory (red) connections. The element, SK receives no input from the other elements. For this reason, we do not consider it as a part of the cell-cycle network, but rather as an external input that serves as a catalyst to initiate cell division. At the micro level, the system comprised of eight elements (in blue) is a stable local maximum of Φ for the duration of the biological sequence. (B) A sequence of 9 states that represent the cell division cycle, called the networks biological sequence.