Additional file 6: of Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy

Figure S4. Chemotherapy dose titration in NSG mice engrafted with KG1a. NSG mice were engrafted with KG1a and a range of chemotherapy doses were tested (n = 3/group). We determined a dose (8 mg/kg AraC + 0.24 mg/kg DNR) that would moderately reduce KG1a engraftment in the bone marrow, determined by flow cytometry analysis (described in Methods), while remaining well below the maximum tolerated dose, as determined by Wunderlich et al. [22]. (TIF 188 kb