Data-model comparisons of respiratory phase dependent photostimulation of pre-BötC neurons.

<p>(<b>A</b>) Five respiratory airflow traces illustrating the response to stimulation of pre-BötC neurons at different respiratory phases. The orange trace indicates a lack of response to photostimulation when it occurs during the post-inspiratory phase (refractory period). The green trace shows a slight prolongation of inspiration (green arrow) when the stimulus is delivered during the inspiratory phase and the black traces show initiation of inspiration during the stimulus after a short latency (based on data from the study of Alsahafi et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006148#pcbi.1006148.ref047" target="_blank">47</a>], <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006148#pcbi.1006148.g007" target="_blank">Fig 7B</a>, used with authors’ permission). (<b>B</b>) The model output traces of pre-I/I and post-I activities show a similar behavior to the experimental data when all pre-BötC populations are stimulated with a 300 ms simulated light pulse. The applied stimulations are shown at the bottom (<i>stim</i>_<i>ChR</i> = 0.2). The timing of the laser stimulus is indicated with blue shading and dashed red lines.