Add to ORKGNonobese diabetic (NOD) mice transgenic for Fas ligand (FasL) on islet β cells (HIPFasL mice) exhibit an accelerated diabetes distinct from the normal autoimmune diabetes of NOD mice. This study was undertaken to define the mechanism underlying accelera
A membrane receptor, Fas (CD95), and its ligand FasL have been considered as key players in diabetes...
Type 1 and type 2 diabetes (T1D and T2D) share pathophysiological characteristics, yet a mechanistic...
Genetically-controlled defects in the development and function of antigen presenting cells may expla...
AbstractImmunologically privileged sites express Fas ligand (FasL), which protects them from attack ...
Fas (Tnfrsf6, Apo-1, CD95) is a death receptor involved in apoptosis induced in many cell types. Fas...
Transgenic insertion of the MHC class II Ea(d)gene in NOD mice restores I-E expression and prevents ...
CD8+ T cells play a central role in beta-cell destruction in type 1 diabetes. CD8+ T cells use two m...
Apoptosis via Fas/Fas ligand (FasL) interactions has been proposed to be a major T-cell-mediated eff...
In diabetic patients and susceptible mice, insulin is a targeted autoantigen. Insulin B chain 9-23 (...
This work introduces and explores a novel model which incorporates Fetal Thymus Organ Culture (FTOC)...
BALB/c mice that express IL-10 as a transgene in their pancreatic β cells (Ins-IL-10 mice) do not de...
Fas ligand (FasL), a type 2 membrane protein belonging to the TNF family, plays an important role in...
The NOD mouse is an established model of autoimmune diabetes mellitus. Various lines of NOD mice dif...
The non-obese diabetic (NOD) mouse represents a relevant animal model of autoimmunity for insulin-de...
Glutamic and decarboxylase (GAD) is a pancreatic β cell autoantigen in humans and nonobese diabetic ...
A membrane receptor, Fas (CD95), and its ligand FasL have been considered as key players in diabetes...
Type 1 and type 2 diabetes (T1D and T2D) share pathophysiological characteristics, yet a mechanistic...
Genetically-controlled defects in the development and function of antigen presenting cells may expla...
AbstractImmunologically privileged sites express Fas ligand (FasL), which protects them from attack ...
Fas (Tnfrsf6, Apo-1, CD95) is a death receptor involved in apoptosis induced in many cell types. Fas...
Transgenic insertion of the MHC class II Ea(d)gene in NOD mice restores I-E expression and prevents ...
CD8+ T cells play a central role in beta-cell destruction in type 1 diabetes. CD8+ T cells use two m...
Apoptosis via Fas/Fas ligand (FasL) interactions has been proposed to be a major T-cell-mediated eff...
In diabetic patients and susceptible mice, insulin is a targeted autoantigen. Insulin B chain 9-23 (...
This work introduces and explores a novel model which incorporates Fetal Thymus Organ Culture (FTOC)...
BALB/c mice that express IL-10 as a transgene in their pancreatic β cells (Ins-IL-10 mice) do not de...
Fas ligand (FasL), a type 2 membrane protein belonging to the TNF family, plays an important role in...
The NOD mouse is an established model of autoimmune diabetes mellitus. Various lines of NOD mice dif...
The non-obese diabetic (NOD) mouse represents a relevant animal model of autoimmunity for insulin-de...
Glutamic and decarboxylase (GAD) is a pancreatic β cell autoantigen in humans and nonobese diabetic ...
A membrane receptor, Fas (CD95), and its ligand FasL have been considered as key players in diabetes...
Type 1 and type 2 diabetes (T1D and T2D) share pathophysiological characteristics, yet a mechanistic...
Genetically-controlled defects in the development and function of antigen presenting cells may expla...