Dietary modification dampens liver inflammation and fibrosis in obesity-related fatty liver disease
- Larter, Claire
- Yeh, Matthew
- Haigh, W Geoffrey
- Van Rooyen, Derrick
- Brooling, John
- Heydet, Deborah
- Nolan, Christopher
- Teoh, Narcissus
- Farrell, Geoffrey
Publication date
February 2016
DOI Publisher
Nature Publishing Group Journal
issn:1930-7381Abstract
Background: Alms1 mutant (foz/foz) mice develop hyperphagic obesity, diabetes, metabolic syndrome, and fatty liver (steatosis). High-fat (HF) feeding converts pathology from bland steatosis to nonalcoholic steatohepatitis (NASH) with fibrosis, which lead
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