The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics

Investigation of the identity of the nucleophile initiating the hydrolysis of phosphate esters catalyzed by dinuclear mimics of metallohydrolases

Brown, Joshua J.
Gahan, Lawrence R.
Schöffler, Anne
Krenske, Elizabeth H.
Schenk, Gerhard

February 2016

di-Zinc(II) complexes of the ligands 2,6-bis((bis(2-methoxyethyl)amino)methyl)-4-methylphenol (HL1),...

A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies

Zee, Yoke Leng Michelle
Gahan, Lawrence R.
Schenk, Gerhard

March 2011

An analogue of the purple acid phosphatase biomimetic 2-((bis(pyridin-2-ylmethyl)amino)methyl)-6-(((...

An Unsymmetric Ligand with a N5O2 Donor Set and Its Corresponding Dizinc Complex : A Structural and Functional Phosphoesterase Model

Das, Biswanath
Daver, Henrik
Pyrkosz-Bulska, Monika
Gumienna-Kontecka, Elzbieta
Himo, Fahmi
Nordlander, Ebbe

January 2018

To mimic the active sites of the hydrolytic enzyme zinc phosphotriesterase, a new dinucleating unsym...

The role of Zn–OR and Zn–OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics

Daumann, Lena J.
Dalle, Kristian E.
Schenk, Gerhard
McGeary, Ross P.
Bernhardt, Paul V.
Ollis, David L.
Gahan, Lawrence R.

January 2012

Analogues of the ligand 2,2′-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis((pyridin-2-ylmethyl...

The role of Zn–OR and Zn–OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics

Daumann, Lena J.
Dalle, Kristian E.
Schenk, Gerhard
McGeary, Ross P.
Bernhardt, Paul V.
Ollis, David L.
Gahan, Lawrence R.

January 2012

Analogues of the ligand 2,2′-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis((pyridin-2-ylmethyl...

The role of Zn–OR and Zn–OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics

Daumann, Lena J.
Dalle, Kristian E.
Schenk, Gerhard
McGeary, Ross P.
Bernhardt, Paul V.
Ollis, David L.
Gahan, Lawrence R.

January 2012

Analogues of the ligand 2,2′-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis((pyridin-2-ylmethyl...

Ligand modifications modulate the mechanism of binuclear phosphatase biomimetics

Dalle, Kristian E.
Daumann, Lena J.
Schenk, Gerhard
McGeary, Ross P.
Hanton, Lyall R.
Gahan, Lawrence R.

March 2013

Complexation of dimethyl-6,6'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis((2-hydroxyethyl) a...

Dinuclear Zinc(II) Complexes with Hydrogen Bond Donors as Structural and Functional Phosphatase Models

Simone Bosch (1558285)
Peter Comba (385228)
Lawrence R. Gahan (1756807)
Gerhard Schenk (1471624)

September 2014

It is becoming increasingly apparent that the secondary coordination sphere can have a crucial role ...

Dinuclear Zinc(II) Complexes with Hydrogen Bond Donors as Structural and Functional Phosphatase Models

Simone Bosch (1558285)
Peter Comba (385228)
Lawrence R. Gahan (1756807)
Gerhard Schenk (1471624)

September 2014

It is becoming increasingly apparent that the secondary coordination sphere can have a crucial role ...

Dinuclear Zinc(II) Complexes with Hydrogen Bond Donors as Structural and Functional Phosphatase Models

Simone Bosch (1558285)
Peter Comba (385228)
Lawrence R. Gahan (1756807)
Gerhard Schenk (1471624)

September 2014

It is becoming increasingly apparent that the secondary coordination sphere can have a crucial role ...

Mechanistic Implications in the Phosphatase Activity of Mannich-Based Dinuclear Zinc Complexes with Theoretical Modeling

Ria Sanyal (1647247)
Xuepeng Zhang (95015)
Priyanka Kundu (803553)
Tanmay Chattopadhyay (1647253)
Cunyuan Zhao (1403302)
Franz A. Mautner (1647250)
Debasis Das (1344114)

March 2015

An “end-off” compartmental ligand has been synthesized by an abnormal Mannich reaction, namely, 2-[b...

Mechanistic Implications in the Phosphatase Activity of Mannich-Based Dinuclear Zinc Complexes with Theoretical Modeling

Ria Sanyal (1647247)
Xuepeng Zhang (95015)
Priyanka Kundu (803553)
Tanmay Chattopadhyay (1647253)
Cunyuan Zhao (1403302)
Franz A. Mautner (1647250)
Debasis Das (1344114)

March 2015

An “end-off” compartmental ligand has been synthesized by an abnormal Mannich reaction, namely, 2-[b...

Asymmetric mono- and dinuclear GaIII and ZnII complexes as models for purple acid phosphatases

Bosch, Simone
Comba, Peter
Gahan, Lawrence R.
Schenk, Gerhard

January 2016

Derivatives of the known dinucleating ligands HL1 (2,6-bis{[bis(pyridin-2-ylmethyl)amino]methyl}-4-m...

Phosphatase models: Synthesis, structure and catalytic activity of zinc complexes derived from a phenolic Mannich-base ligand

Sanyal, Ria
Chakraborty, Prateeti
Zangrando, Ennio
Das, Debasis

January 2015

A series of dinuclear [Zn2(L1)2X2] (1\u20133) and mononuclear [Zn(HL2)X2] complexes (4\u20136), (X =...

Mechanistic Implications in the Phosphatase Activity of Mannich-Based Dinuclear Zinc Complexes with Theoretical Modeling

Ria Sanyal (1647247)
Xuepeng Zhang (95015)
Priyanka Kundu (803553)
Tanmay Chattopadhyay (1647253)
Cunyuan Zhao (1403302)
Franz A. Mautner (1647250)
Debasis Das (1344114)

March 2015

An “end-off” compartmental ligand has been synthesized by an abnormal Mannich reaction, namely, 2-[b...

Investigation of the identity of the nucleophile initiating the hydrolysis of phosphate esters catalyzed by dinuclear mimics of metallohydrolases

Brown, Joshua J.
Gahan, Lawrence R.
Schöffler, Anne
Krenske, Elizabeth H.
Schenk, Gerhard

February 2016

di-Zinc(II) complexes of the ligands 2,6-bis((bis(2-methoxyethyl)amino)methyl)-4-methylphenol (HL1),...

A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies

Zee, Yoke Leng Michelle
Gahan, Lawrence R.
Schenk, Gerhard

March 2011

An analogue of the purple acid phosphatase biomimetic 2-((bis(pyridin-2-ylmethyl)amino)methyl)-6-(((...

An Unsymmetric Ligand with a N5O2 Donor Set and Its Corresponding Dizinc Complex : A Structural and Functional Phosphoesterase Model

Das, Biswanath
Daver, Henrik
Pyrkosz-Bulska, Monika
Gumienna-Kontecka, Elzbieta
Himo, Fahmi
Nordlander, Ebbe

January 2018

To mimic the active sites of the hydrolytic enzyme zinc phosphotriesterase, a new dinucleating unsym...

The role of Zn–OR and Zn–OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics

Daumann, Lena J.
Dalle, Kristian E.
Schenk, Gerhard
McGeary, Ross P.
Bernhardt, Paul V.
Ollis, David L.
Gahan, Lawrence R.

January 2012

Analogues of the ligand 2,2′-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis((pyridin-2-ylmethyl...

The role of Zn–OR and Zn–OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics

Daumann, Lena J.
Dalle, Kristian E.
Schenk, Gerhard
McGeary, Ross P.
Bernhardt, Paul V.
Ollis, David L.
Gahan, Lawrence R.

January 2012

Analogues of the ligand 2,2′-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis((pyridin-2-ylmethyl...

The role of Zn–OR and Zn–OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics

Daumann, Lena J.
Dalle, Kristian E.
Schenk, Gerhard
McGeary, Ross P.
Bernhardt, Paul V.
Ollis, David L.
Gahan, Lawrence R.

January 2012

Analogues of the ligand 2,2′-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis((pyridin-2-ylmethyl...

Ligand modifications modulate the mechanism of binuclear phosphatase biomimetics

Dalle, Kristian E.
Daumann, Lena J.
Schenk, Gerhard
McGeary, Ross P.
Hanton, Lyall R.
Gahan, Lawrence R.

March 2013

Complexation of dimethyl-6,6'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis((2-hydroxyethyl) a...

Dinuclear Zinc(II) Complexes with Hydrogen Bond Donors as Structural and Functional Phosphatase Models

Simone Bosch (1558285)
Peter Comba (385228)
Lawrence R. Gahan (1756807)
Gerhard Schenk (1471624)

September 2014

It is becoming increasingly apparent that the secondary coordination sphere can have a crucial role ...

Dinuclear Zinc(II) Complexes with Hydrogen Bond Donors as Structural and Functional Phosphatase Models

Simone Bosch (1558285)
Peter Comba (385228)
Lawrence R. Gahan (1756807)
Gerhard Schenk (1471624)

September 2014

It is becoming increasingly apparent that the secondary coordination sphere can have a crucial role ...

Dinuclear Zinc(II) Complexes with Hydrogen Bond Donors as Structural and Functional Phosphatase Models

Simone Bosch (1558285)
Peter Comba (385228)
Lawrence R. Gahan (1756807)
Gerhard Schenk (1471624)

September 2014

It is becoming increasingly apparent that the secondary coordination sphere can have a crucial role ...

Mechanistic Implications in the Phosphatase Activity of Mannich-Based Dinuclear Zinc Complexes with Theoretical Modeling

Ria Sanyal (1647247)
Xuepeng Zhang (95015)
Priyanka Kundu (803553)
Tanmay Chattopadhyay (1647253)
Cunyuan Zhao (1403302)
Franz A. Mautner (1647250)
Debasis Das (1344114)

March 2015

An “end-off” compartmental ligand has been synthesized by an abnormal Mannich reaction, namely, 2-[b...

Mechanistic Implications in the Phosphatase Activity of Mannich-Based Dinuclear Zinc Complexes with Theoretical Modeling

Ria Sanyal (1647247)
Xuepeng Zhang (95015)
Priyanka Kundu (803553)
Tanmay Chattopadhyay (1647253)
Cunyuan Zhao (1403302)
Franz A. Mautner (1647250)
Debasis Das (1344114)

March 2015

An “end-off” compartmental ligand has been synthesized by an abnormal Mannich reaction, namely, 2-[b...

Asymmetric mono- and dinuclear GaIII and ZnII complexes as models for purple acid phosphatases

Bosch, Simone
Comba, Peter
Gahan, Lawrence R.
Schenk, Gerhard

January 2016

Derivatives of the known dinucleating ligands HL1 (2,6-bis{[bis(pyridin-2-ylmethyl)amino]methyl}-4-m...

Phosphatase models: Synthesis, structure and catalytic activity of zinc complexes derived from a phenolic Mannich-base ligand

Sanyal, Ria
Chakraborty, Prateeti
Zangrando, Ennio
Das, Debasis

January 2015

A series of dinuclear [Zn2(L1)2X2] (1\u20133) and mononuclear [Zn(HL2)X2] complexes (4\u20136), (X =...

Mechanistic Implications in the Phosphatase Activity of Mannich-Based Dinuclear Zinc Complexes with Theoretical Modeling

Ria Sanyal (1647247)
Xuepeng Zhang (95015)
Priyanka Kundu (803553)
Tanmay Chattopadhyay (1647253)
Cunyuan Zhao (1403302)
Franz A. Mautner (1647250)
Debasis Das (1344114)

March 2015

An “end-off” compartmental ligand has been synthesized by an abnormal Mannich reaction, namely, 2-[b...

Investigation of the identity of the nucleophile initiating the hydrolysis of phosphate esters catalyzed by dinuclear mimics of metallohydrolases

Brown, Joshua J.
Gahan, Lawrence R.
Schöffler, Anne
Krenske, Elizabeth H.
Schenk, Gerhard

February 2016

di-Zinc(II) complexes of the ligands 2,6-bis((bis(2-methoxyethyl)amino)methyl)-4-methylphenol (HL1),...

A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies

Zee, Yoke Leng Michelle
Gahan, Lawrence R.
Schenk, Gerhard

March 2011

An analogue of the purple acid phosphatase biomimetic 2-((bis(pyridin-2-ylmethyl)amino)methyl)-6-(((...

An Unsymmetric Ligand with a N5O2 Donor Set and Its Corresponding Dizinc Complex : A Structural and Functional Phosphoesterase Model

Das, Biswanath
Daver, Henrik
Pyrkosz-Bulska, Monika
Gumienna-Kontecka, Elzbieta
Himo, Fahmi
Nordlander, Ebbe

January 2018

To mimic the active sites of the hydrolytic enzyme zinc phosphotriesterase, a new dinucleating unsym...

The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics

Abstract

Extracted data

The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics

Abstract

Extracted data

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