Analysis of Complement Expression in Light-Induced Retinal Degeneration: Synthesis and Deposition of C3 by Microglia/Macrophages Is Associated with Focal Photoreceptor Degeneration
- Rutar, Matthew
- Natoli, Riccardo
- Kozulin, Peter
- Valter (Valter-Kocsi), Krisztina
- Gatenby, Paul
- Provis, Jan
Publication date
February 2016
DOI Publisher
Association for Research in Vision and Ophthalmology (ARVO) Journal
Investigative Opthalmology & Visual Science Language
EnglishAbstract
Purpose. To investigate the expression and localization of complement system mRNA and protein in a light-induced model of progressive retinal degeneration. Methods. Sprague-Dawley (SD) rats were exposed to 1000 lux of bright continuous light (BCL) for u
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