Unique IL-13Ralpha2-based HIV-1 vaccine strategy to enhance mucosal immunity, CD8 þ T-cell avidity and protective immunity

We have established that mucosal immunization can generate high-avidity human immunodeficiency virus (HIV)-specific CD8 + T cells compared with systemic immunization, and interleukin (IL)-13 is detrimental to the functional avidity of these T cells. We h