The molecular chaperone αB-crystallin is a small heat-shock protein that is upregulated in response to a multitude of stress stimuli, and is found colocalized with Aβ amyloid fibrils in the extracellular plaques that are characteristic of Alzheimer's disease. We investigated whether this archetypical small heat-shock protein has the ability to interact with Aβ fibrils in vitro. We find that αB-crystallin binds to wild-type Aβ(42) fibrils with micromolar affinity, and also binds to fibrils formed from the E22G Arctic mutation of Aβ(42). Immunoelectron microscopy confirms that binding occurs along the entire length and ends of the fibrils. Investigations into the effect of αB-crystallin on the seeded growth of Aβ fibrils, both in solution and...
α-Synuclein is a pre-synaptic protein, the function of which is not completely understood, but its p...
AlphaB-Crystallin is a ubiquitous small heat-shock protein (sHsp) renowned for its chaperone ability...
Background. Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease are associated with inappropriate...
AbstractThe molecular chaperone αB-crystallin is a small heat-shock protein that is upregulated in r...
The molecular chaperone αB-crystallin is a small heat-shock protein that is upregulated in response ...
The molecular chaperone aB-crystallin is a small heat-shock protein that is upregulated in response ...
AbstractαB-Crystallin is a small heat-shock protein (sHsp) that is colocalized with α-synuclein (αSy...
alphaB-Crystallin is a small heat-shock protein (sHsp) that is colocalized with alpha-synuclein (alp...
αB-Crystallin is a small heat-shock protein (sHsp) that is colocalized with α-synuclein (αSyn) in Le...
© 2020 Selig et al. Small heat-shock proteins (sHSPs) are ubiquitously expressed molecular chaperone...
αB-Crystallin is a ubiquitous small heat-shock protein (sHsp) renowned for its chaperone ability to ...
The in vivo aggregation of proteins into amyloid fibrils suggests that cellular mechanisms that norm...
The in vivo aggregation of proteins into amyloid fibrils suggests that cellular mechanisms that norm...
αB-Crystallin is a ubiquitous small heat-shock protein (sHsp) renowned for its chaperone ability to ...
Amyloid fibril formation is associated with diseases such as Alzheimer’s, Parkinson’s, and prion dis...
α-Synuclein is a pre-synaptic protein, the function of which is not completely understood, but its p...
AlphaB-Crystallin is a ubiquitous small heat-shock protein (sHsp) renowned for its chaperone ability...
Background. Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease are associated with inappropriate...
AbstractThe molecular chaperone αB-crystallin is a small heat-shock protein that is upregulated in r...
The molecular chaperone αB-crystallin is a small heat-shock protein that is upregulated in response ...
The molecular chaperone aB-crystallin is a small heat-shock protein that is upregulated in response ...
AbstractαB-Crystallin is a small heat-shock protein (sHsp) that is colocalized with α-synuclein (αSy...
alphaB-Crystallin is a small heat-shock protein (sHsp) that is colocalized with alpha-synuclein (alp...
αB-Crystallin is a small heat-shock protein (sHsp) that is colocalized with α-synuclein (αSyn) in Le...
© 2020 Selig et al. Small heat-shock proteins (sHSPs) are ubiquitously expressed molecular chaperone...
αB-Crystallin is a ubiquitous small heat-shock protein (sHsp) renowned for its chaperone ability to ...
The in vivo aggregation of proteins into amyloid fibrils suggests that cellular mechanisms that norm...
The in vivo aggregation of proteins into amyloid fibrils suggests that cellular mechanisms that norm...
αB-Crystallin is a ubiquitous small heat-shock protein (sHsp) renowned for its chaperone ability to ...
Amyloid fibril formation is associated with diseases such as Alzheimer’s, Parkinson’s, and prion dis...
α-Synuclein is a pre-synaptic protein, the function of which is not completely understood, but its p...
AlphaB-Crystallin is a ubiquitous small heat-shock protein (sHsp) renowned for its chaperone ability...
Background. Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease are associated with inappropriate...