Objective. Cardiac neonatal lupus (cardiac-NL), initiated by surface binding of anti-Ro60 autoantibodies to apoptotic cardiocytes during development, activates the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system. Subsequent accumulation of apoptotic cells and plasmin generation facilitates increased binding of anti-Ro60 by disrupting and cleaving circulating β2-glycoprotein I (β2GPI) thereby eliminating its protective effect. The association of soluble levels of components of the uPA/uPAR system with cardiac-NL was examined. Methods. Levels of the uPA/uPAR system were assessed by ELISA in cord blood and immunohistological evaluation of autopsies. Results. uPA, uPAR and plasminogen levels were e...
Congenital heart block (CHB) develops in fetuses of Ro/SSA and La/SSB positive women. During pregnan...
The urokinase receptor (urokinase plasminogen activator receptor; uPAR) regulates monocyte adhesion ...
Copyright © 2002 American College of Rheumatology The definitive version may be found at www.wiley....
AbstractBackgroundCardiac manifestations of neonatal lupus (cardiac NL) include congenital heart blo...
Objective Maternal anti-Ro autoantibodies are associated with cardiac manifestations of neonatal lu...
Neonatal lupus erythematosus (NLE) is an auto-immune disease related to systemic lupus erythematosus...
ObjectivesThe purpose of this study was to determine whether cardiac complications of neonatal lupus...
The study of the mechanisms of development and progression of fibrosis is one of the key directions ...
A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the repe...
The prevalence of autoantibodies to ribonucleoprotein antigens in cases of congenital heart block wa...
Aims Peripartum cardiomyopathy (PPCM) is a life-threatening heart disease occurring in previously he...
Cardiac neonatal lupus (NL) is presumed to arise from maternal autoantibody targeting an intracellul...
Objective: Inflammation and fibrosis are intertwined in multiple disease processes. We have previous...
Objective: Neonatal lupus erythematosus (NLE) may develop after transplacental transfer of maternal ...
Printed by Neonatal lupus erythematosus (NLE) affects neonates of Ro/SSA and La/SSB positive women. ...
Congenital heart block (CHB) develops in fetuses of Ro/SSA and La/SSB positive women. During pregnan...
The urokinase receptor (urokinase plasminogen activator receptor; uPAR) regulates monocyte adhesion ...
Copyright © 2002 American College of Rheumatology The definitive version may be found at www.wiley....
AbstractBackgroundCardiac manifestations of neonatal lupus (cardiac NL) include congenital heart blo...
Objective Maternal anti-Ro autoantibodies are associated with cardiac manifestations of neonatal lu...
Neonatal lupus erythematosus (NLE) is an auto-immune disease related to systemic lupus erythematosus...
ObjectivesThe purpose of this study was to determine whether cardiac complications of neonatal lupus...
The study of the mechanisms of development and progression of fibrosis is one of the key directions ...
A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the repe...
The prevalence of autoantibodies to ribonucleoprotein antigens in cases of congenital heart block wa...
Aims Peripartum cardiomyopathy (PPCM) is a life-threatening heart disease occurring in previously he...
Cardiac neonatal lupus (NL) is presumed to arise from maternal autoantibody targeting an intracellul...
Objective: Inflammation and fibrosis are intertwined in multiple disease processes. We have previous...
Objective: Neonatal lupus erythematosus (NLE) may develop after transplacental transfer of maternal ...
Printed by Neonatal lupus erythematosus (NLE) affects neonates of Ro/SSA and La/SSB positive women. ...
Congenital heart block (CHB) develops in fetuses of Ro/SSA and La/SSB positive women. During pregnan...
The urokinase receptor (urokinase plasminogen activator receptor; uPAR) regulates monocyte adhesion ...
Copyright © 2002 American College of Rheumatology The definitive version may be found at www.wiley....