TRPV4 mediated cytokine release.
- N. Pairet (5109128)
- S. Mang (5109134)
- G. Fois (5109146)
- M. Keck (4224400)
- M. Kühnbach (5109137)
- J. Gindele (5109131)
- M. Frick (5109140)
- P. Dietl (5109143)
- D. J. Lamb (5109125)
Publication date
April 2018
DOIAbstract
<p>Representative experiment of NCI-H292 cells incubated for 24 h in the presence or absence of the TRPV4 agonist GSK1016790A [3nM] (ag) with or without pre-treatment with the TRPV4-Antagonist GSK2193874 [1<b>μ</b>M] (ant). (A,B) release of IL-6 and IL-8 through TRPV4 activation compared to medium (ctrl) and DMSO control (veh) that could be blocked by the TRPV4 antagonist. (C,D) TRPV4 mediated release of IL-1α and MDC. Data are mean ± SEM; (n = 6; ****p ˂ 0.0001 vs agonist control; one-way ANOVA Tukey's multiple comparisons test).</p
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