±PZQ causes relaxation of precontracted mesenteric arteries.

<p>(<b>A</b>) Changes in tension measured in mouse mesenteric artery vessel strips evoked by KPSS (left, arrow), ±PZQ (circle, 100μM) added at basal tone (middle) and KPSS (arrow) followed by addition of ±PZQ to a contracted vessel (purple circle and trace, right). Solution exchanges to physiological saline shown as ‘w’ (wash). (<b>B</b>) Dose-response relationship quantifying peak relaxation evoked by indicated concentrations of ±PZQ. (<b>C</b>) Effect of repeated additions of ±PZQ (10μM, black circles) without solution exchange on contractile tone in a vessel contracted by solution exchange to KPSS (arrow).