ΔCCR5 cells persist in tissues of SHIV⁺ animals.

<p>Tissues were collected longitudinally (figure panels <b>[A-B]</b>) or at necropsy (panels <b>[C-E]</b>) from transplanted animals, and the percentage of CCR5-edited alleles was quantified from total tissue homogenate by Illumina MiSeq. <b>(A)</b> Duodenum/Jejunum (Upper GI), colon (Lower GI) and peripheral lymph nodes from Group A animals transplanted prior to SHIV challenge. <b>(B)</b> Same as panel A, from Group B-C animals transplanted following SHIV infection and stable suppression by cART. <b>(C)</b> Necropsy tissues from Group A animals as in panel A. <b>(D)</b> Necropsy tissues from Group B animals in panel B that were necropsied following cART withdrawal. <b>(E)</b> Necropsy tissues from Group C animals in panel B that were necropsied while stably suppressed on cART.