Impact of myeloablative conditioning and ΔCCR5 HSPCs on the size of the peripheral SHIV reservoir.

<p>Quantitative viral outgrowth assay (QVOA) was used to measure the size of the latent SHIV reservoir in Group B-C animals (n = 7) that were sampled before and after ΔCCR5 transplantation. An arbitrary value of 0.01 was used for animals in which the viral reservoir was undetectable. “Undetectable” is defined as no p27 ELISA-positive signal, despite seeding of replicate wells with up to 5x10⁶ input CD4⁺ T-cells.