Ask
Search
My library
ORKG

ORKG Ask

Our mission is to organize scholarly knowledge and make it accessible to humans and machines.

About

About ORKG Ask
Report issue
Statistics
Contact

Legal

Terms of use
Data protection (sheet)
Imprint
Accessibility
License

Technical

We
open source
System status
Changelog
Frontend: v1.41.0
Backend: v1.13.4

We use cookies to provide a better user experience.

Data Protection

Changes in accumulation of LCBs and phospho-LCBs in response to SphK expression and SphK inhibition.

Yugesh Kharel (1403173)
Sayeh Agah (2711812)
Tao Huang (110613)
Anna J. Mendelson (5122196)
Oluwafunmilayo T. Eletu (5122205)
Peter Barkey-Bircann (5122202)
James Gesualdi (5122199)
Jeffrey S. Smith (77927)
Webster L. Santos (1403167)
Kevin R. Lynch (701811)

Publication date

April 2018

DOI

10.1371/journal.pone.0192179.g005

Abstract

<p>Changes in accumulation of LCBs and phospho-LCBs in response to SphK expression and SphK inhibition.</p

Extracted data

Related items

The influence of PKA activity inhibition on the HSL expression level and lipolysis by LF.

Keiko Ikoma-Seki (818838)
Kanae Nakamura (818839)
Satoru Morishita (818840)
Tomoji Ono (818841)
Keikichi Sugiyama (818842)
Hoyoku Nishino (818843)
Hisashi Hirano (209755)
Michiaki Murakoshi (818844)

October 2015

<p><b>(A)</b> Change in expression levels of HSL by LF. The protein expression levels of HSL were de...

Identification and characterization of the sites of mitotic serine phosphorylation in Lck

Kesavan, Kamala Padma

January 1999

Lck is a member of the Src family of non-receptor protein tyrosine kinases that plays a critical rol...

PKC induces the LKB1-AMPK-Syk signal pathway.

Mei-Ying Chang (314118)
Duen-Yi Huang (10888)
Feng-Ming Ho (314120)
Kuo-Chin Huang (283999)
Wan-Wan Lin (314121)

February 2013

<p>(<b>A</b>) THP-1 cells were treated with inhibitors for 30 min, followed by PMA (100 nM) for the ...

Quantitative measurements of the changes in phosphopeptide amounts brought by LIMK inhibition.

Renaud Prudent (454502)
Nathalie Demoncheaux (6087065)
Hélène Diemer (226798)
Véronique Collin-Faure (728391)
Reuben Kapur (143722)
Fabrice Paublant (6087068)
Laurence Lafanechère (454504)
Sarah Cianférani (542005)
Thierry Rabilloud (728396)

December 2018

The data are expressed in fold-changes in the phosphopeptides amounts in the phosphocofilin spot (co...

Effect of LCs on ERK1/2 and p38 MAPK (immunoblots on the left side of the panel with corresponding bar graphs of densitometric measurements next to each immunoblot panel.

Sule Sengul (435910)
Sehsuvar Erturk (435911)
Altaf M. Khan (435912)
Vecihi Batuman (435913)

July 2013

<p>Panel <b>A</b> shows inhibition of light chain (LC)-stimulated phosphorylation of ERK ½, and pane...

Yukari Yamane-s
Etsuko Shimobayashi
Mitsugu Shimobayashi
Yasunori Kozutsumi

January 2014

Fpk1/2 kinases regulate cellular sphingoid long-chain base abundance and alter cellular resistance t...

LKB1 levels and substrate activation increases, and LKB1 redistributes to the cytoplasm during differentiation.

Isma Mian (183543)
Willythssa Stéphie Pierre-Louis (183546)
Neha Dole (183549)
Renée M. Gilberti (183553)
Kimberly Dodge-Kafka (183559)
Jennifer S. Tirnauer (183564)

February 2012

<p>(A) Western blotting was done on samples from the indicated days of differentiation. Myosin heavy...

Changes in the phosphorylation of nucleotide metabolism‑associated proteins by leukemia inhibitory factor in mouse embryonic stem cells

김현이

June 2021

Leukemia inhibitory factor (LIF) is a stem cell growth factor that maintains self‑renewal of mouse e...

Effects of SPHK inhibition in colony formation assays.

Karen Rex (431185)
Shawn Jeffries (431186)
Matthew L. Brown (431187)
Timothy Carlson (431188)
Angela Coxon (431189)
Flordeliza Fajardo (431190)
Brendon Frank (431191)
Darin Gustin (431192)
Alexander Kamb (26291)
Paul D. Kassner (427256)
Shyun Li (431193)
Yihong Li (105659)
Kurt Morgenstern (431194)
Matthew Plant (431195)
Kim Quon (427255)
Astrid Ruefli-Brasse (106979)
Joanna Schmidt (431196)
Elissa Swearingen (431197)
Nigel Walker (431198)
Zhulun Wang (431199)
J. E. Vivienne Watson (431200)
Dineli Wickramasinghe (106976)
Mariwil Wong (431201)
Guifen Xu (431202)
Holger Wesche (240743)

July 2013

<p>LN229 cells were seeded at a density of 800 cells/well in a six well plate in the presence of the...

p38 MAPK inhibition reduces negative impact of Pb on the main hMESCs properties during LV transduction.

Anastasiia Griukova (6158006)
Pavel Deryabin (6158009)
Maria Sirotkina (6158012)
Alla Shatrova (6158015)
Nikolay Nikolsky (6158018)
Aleksandra Borodkina (6158021)

December 2018

“Ctr”–control cells. “Pb+LV”–the cells infected by LV with 4 μg/ml of Pb. “(Pb+LV)+SB”–the cells inf...

Regulation of lymphocyte specific protein tyrosine kinase, Lck, by tyrosine phosphorylation : evaluation of the tail-bite model

Hatahet, Laith

January 2003

Several studies show that the catalytic function of the Src-family protein kinase Lck is repressed ...

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.

Courtney, Adam H
Amacher, Jeanine F
Kadlecek, Theresa A
Mollenauer, Marianne N
Au-Yeung, Byron B
Kuriyan, John
Weiss, Arthur

August 2017

The Src Family kinase Lck sets a critical threshold for T cell activation because it phosphoryl...

Protein fingerprints of cllular effects of inhibition of cycli-dependent kinases can indicate development of chemoresistance of tunour cells

Kovářová, H.

January 2003

Cyclin-dependent kinases regulate cell division cycle, apoptosis, transcription, and differentiotion

To be or not to be activated: current view on the regulation of Lck in the proximal T-cell signaling

Valečka, Jan

January 2011

Src-family kinases are critical members of many signalling pathways present in many cell types. Lck,...

Treatment with pUL11Fc affects phosphorylation of the regulatory tyrosines of Lck.

Jasmin Zischke (4117486)
Panagiota Mamareli (4028822)
Claudia Pokoyski (193131)
Ildar Gabaev (193128)
Sabine Buyny (4117489)
Roland Jacobs (193166)
Christine S. Falk (111916)
Matthias Lochner (49323)
Tim Sparwasser (128746)
Thomas F. Schulz (193151)
Penelope C. Kay-Fedorov (193181)

June 2017

<p>PBMC were incubated with anti-CD3 (OKT3) in the presence or absence of UL11Fc and Fc at the indic...

The influence of PKA activity inhibition on the HSL expression level and lipolysis by LF.

Keiko Ikoma-Seki (818838)
Kanae Nakamura (818839)
Satoru Morishita (818840)
Tomoji Ono (818841)
Keikichi Sugiyama (818842)
Hoyoku Nishino (818843)
Hisashi Hirano (209755)
Michiaki Murakoshi (818844)

October 2015

<p><b>(A)</b> Change in expression levels of HSL by LF. The protein expression levels of HSL were de...

Identification and characterization of the sites of mitotic serine phosphorylation in Lck

Kesavan, Kamala Padma

January 1999

Lck is a member of the Src family of non-receptor protein tyrosine kinases that plays a critical rol...

PKC induces the LKB1-AMPK-Syk signal pathway.

Mei-Ying Chang (314118)
Duen-Yi Huang (10888)
Feng-Ming Ho (314120)
Kuo-Chin Huang (283999)
Wan-Wan Lin (314121)

February 2013

<p>(<b>A</b>) THP-1 cells were treated with inhibitors for 30 min, followed by PMA (100 nM) for the ...

Quantitative measurements of the changes in phosphopeptide amounts brought by LIMK inhibition.

Renaud Prudent (454502)
Nathalie Demoncheaux (6087065)
Hélène Diemer (226798)
Véronique Collin-Faure (728391)
Reuben Kapur (143722)
Fabrice Paublant (6087068)
Laurence Lafanechère (454504)
Sarah Cianférani (542005)
Thierry Rabilloud (728396)

December 2018

The data are expressed in fold-changes in the phosphopeptides amounts in the phosphocofilin spot (co...

Effect of LCs on ERK1/2 and p38 MAPK (immunoblots on the left side of the panel with corresponding bar graphs of densitometric measurements next to each immunoblot panel.

Sule Sengul (435910)
Sehsuvar Erturk (435911)
Altaf M. Khan (435912)
Vecihi Batuman (435913)

July 2013

<p>Panel <b>A</b> shows inhibition of light chain (LC)-stimulated phosphorylation of ERK ½, and pane...

Yukari Yamane-s
Etsuko Shimobayashi
Mitsugu Shimobayashi
Yasunori Kozutsumi

January 2014

Fpk1/2 kinases regulate cellular sphingoid long-chain base abundance and alter cellular resistance t...

LKB1 levels and substrate activation increases, and LKB1 redistributes to the cytoplasm during differentiation.

Isma Mian (183543)
Willythssa Stéphie Pierre-Louis (183546)
Neha Dole (183549)
Renée M. Gilberti (183553)
Kimberly Dodge-Kafka (183559)
Jennifer S. Tirnauer (183564)

February 2012

<p>(A) Western blotting was done on samples from the indicated days of differentiation. Myosin heavy...

Changes in the phosphorylation of nucleotide metabolism‑associated proteins by leukemia inhibitory factor in mouse embryonic stem cells

김현이

June 2021

Leukemia inhibitory factor (LIF) is a stem cell growth factor that maintains self‑renewal of mouse e...

Effects of SPHK inhibition in colony formation assays.

Karen Rex (431185)
Shawn Jeffries (431186)
Matthew L. Brown (431187)
Timothy Carlson (431188)
Angela Coxon (431189)
Flordeliza Fajardo (431190)
Brendon Frank (431191)
Darin Gustin (431192)
Alexander Kamb (26291)
Paul D. Kassner (427256)
Shyun Li (431193)
Yihong Li (105659)
Kurt Morgenstern (431194)
Matthew Plant (431195)
Kim Quon (427255)
Astrid Ruefli-Brasse (106979)
Joanna Schmidt (431196)
Elissa Swearingen (431197)
Nigel Walker (431198)
Zhulun Wang (431199)
J. E. Vivienne Watson (431200)
Dineli Wickramasinghe (106976)
Mariwil Wong (431201)
Guifen Xu (431202)
Holger Wesche (240743)

July 2013

<p>LN229 cells were seeded at a density of 800 cells/well in a six well plate in the presence of the...

p38 MAPK inhibition reduces negative impact of Pb on the main hMESCs properties during LV transduction.

Anastasiia Griukova (6158006)
Pavel Deryabin (6158009)
Maria Sirotkina (6158012)
Alla Shatrova (6158015)
Nikolay Nikolsky (6158018)
Aleksandra Borodkina (6158021)

December 2018

“Ctr”–control cells. “Pb+LV”–the cells infected by LV with 4 μg/ml of Pb. “(Pb+LV)+SB”–the cells inf...

Regulation of lymphocyte specific protein tyrosine kinase, Lck, by tyrosine phosphorylation : evaluation of the tail-bite model

Hatahet, Laith

January 2003

Several studies show that the catalytic function of the Src-family protein kinase Lck is repressed ...

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.

Courtney, Adam H
Amacher, Jeanine F
Kadlecek, Theresa A
Mollenauer, Marianne N
Au-Yeung, Byron B
Kuriyan, John
Weiss, Arthur

August 2017

The Src Family kinase Lck sets a critical threshold for T cell activation because it phosphoryl...

Protein fingerprints of cllular effects of inhibition of cycli-dependent kinases can indicate development of chemoresistance of tunour cells

Kovářová, H.

January 2003

Cyclin-dependent kinases regulate cell division cycle, apoptosis, transcription, and differentiotion

To be or not to be activated: current view on the regulation of Lck in the proximal T-cell signaling

Valečka, Jan

January 2011

Src-family kinases are critical members of many signalling pathways present in many cell types. Lck,...

Treatment with pUL11Fc affects phosphorylation of the regulatory tyrosines of Lck.

Jasmin Zischke (4117486)
Panagiota Mamareli (4028822)
Claudia Pokoyski (193131)
Ildar Gabaev (193128)
Sabine Buyny (4117489)
Roland Jacobs (193166)
Christine S. Falk (111916)
Matthias Lochner (49323)
Tim Sparwasser (128746)
Thomas F. Schulz (193151)
Penelope C. Kay-Fedorov (193181)

June 2017

<p>PBMC were incubated with anti-CD3 (OKT3) in the presence or absence of UL11Fc and Fc at the indic...

The influence of PKA activity inhibition on the HSL expression level and lipolysis by LF.

Keiko Ikoma-Seki (818838)
Kanae Nakamura (818839)
Satoru Morishita (818840)
Tomoji Ono (818841)
Keikichi Sugiyama (818842)
Hoyoku Nishino (818843)
Hisashi Hirano (209755)
Michiaki Murakoshi (818844)

October 2015

<p><b>(A)</b> Change in expression levels of HSL by LF. The protein expression levels of HSL were de...

Identification and characterization of the sites of mitotic serine phosphorylation in Lck

Kesavan, Kamala Padma

January 1999

Lck is a member of the Src family of non-receptor protein tyrosine kinases that plays a critical rol...

PKC induces the LKB1-AMPK-Syk signal pathway.

Mei-Ying Chang (314118)
Duen-Yi Huang (10888)
Feng-Ming Ho (314120)
Kuo-Chin Huang (283999)
Wan-Wan Lin (314121)

February 2013

<p>(<b>A</b>) THP-1 cells were treated with inhibitors for 30 min, followed by PMA (100 nM) for the ...