CD4<sup>+</sup>, CD8<sup>+</sup> and Ki-67 <sup>+</sup> expression and cytokines/mm<sup>2</sup> splenic tissue of dogs naturally infected with <i>L</i>. <i>infantum</i>.
- Aurea Virginia Andrade da Silva (5125817)
- Fabiano Borges Figueiredo (437925)
- Rodrigo Caldas Menezes (3931940)
- Arthur Augusto Mendes-Junior (5125820)
- Luisa Helena Monteiro de Miranda (5125823)
- Elisa Cupolillo (123796)
- Renato Porrozzi (165892)
- Fernanda Nazaré Morgado (496317)
DOIAbstract
<p>(A-B) Negative control (suppression of primary antibody). Immunostaining of (C-D) CD3<sup>+</sup>, (E) CD4<sup>+</sup>, (F) CD8<sup>+</sup>, (G) CD21<sup>+</sup>, (H) Ki-67<sup>+</sup> proliferating, (I) IFN-ɣ<sup>+</sup> and (J) IL-10<sup>+</sup> cells. Magnification in A and C: 100x; Magnification in B and D-J: 400x. Scale bar = 25 μm. (L) CD4<sup>+</sup> T cells/mm<sup>2</sup>. (M) CD8<sup>+</sup> T cells/mm<sup>2</sup>. (N) CD21<sup>+</sup> B cells/mm<sup>2</sup>. (O) Expression of IFN-ɣ/mm<sup>2</sup>; (P) IL-10/mm<sup>2</sup>; (Q) KI-67<sup>+</sup> cells/mm<sup>2</sup>. Mann-Whitney test. OR-SD = animals with organized to slightly disorganized splenic white pulp. MD-ID = animals with moderately to intensely disorganized splenic whi...
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