Structured models of cell migration incorporating molecular binding processes

DT and MAJC gratefully acknowledge the support of the ERC Advanced Investigator Grant 227619, “M5CGS - From Mutations to Metastases: Multiscale Mathematical Modelling of Cancer Growth and Spread”.The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes allows a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this paper we establish a general spatio-temporal-structural framework that enables the description of molecular binding to cell membranes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with three examples arising from cancer invasion.PostprintPeer reviewe