Independent and Joint Association of Blood Pressure, Serum Total Homocysteine, and Fasting Serum Glucose Levels With Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults

This study aimed to investigate the independent and joint association of blood pressure (BP), homocysteine (Hcy), and fasting blood glucose (FBG) levels with brachial-ankle pulse wave velocity (baPWV, a measure of arterial stiffness) in Chinese hypertensive adults. The analyses included 3967 participants whose BP, Hcy, FBG, and baPWV were measured along with other covariates. Systolic BP (SBP) was analyzed as 3 categories (SBP < 160 mmHg; 160 to 179 mmHg; 180 mmHg); Hcy as 3 categories (< 10 mu mol/L; 10 to 14.9 mu mol/L; >= 15.0 mu mol/L) and FBG: normal (FBG < 5.6 mmol/L), impaired (5.6 mmol/L <= FBG < 7.0 mmol/L), and diabetes mellitus (FBG >= 7.0 mmol/L). We performed linear regression analyses to evaluate their associations with baPWV with adjustment for covariables. When analyzed individually, BP, Hcy, and FBG were each associated with baPWV. When BP and FBG were analyzed jointly, the highest baPWV value (mean +/- SD: 2227 +/- 466 cm/s) was observed in participants with FBG >= 7.0 mmol/L and SBP >= 180 mmHg (beta = 432.5, P < 0.001), and the lowest baPWV value (mean +/- SD: 1692 +/- 289 cm/s) was seen in participants with NFG and SBP < 160 mmHg. When Hcy and FBG were analyzed jointly, the highest baPWV value (2072 +/- 480 cm/s) was observed in participants with FBG >= 7.0 mmol/L and Hcy >= 15.0 mu mol/L (beta = 167.6, P < 0.001), while the lowest baPWV value (mean +/- SD: 1773 +/- 334 cm/s) was observed in participants with NFG and Hcy < 10 mu mol/L. In Chinese hypertensive adults, SBP, Hcy, and FBG are individually and jointly associated with baPWV. Our findings underscore the importance of identifying individuals with multiple risk factors of baPWV including high SBP, FBG, and Hcy.Projects of the National Natural Science Foundation of China [81473052]; National Clinical Research Center for Kidney Disease; Nanfang Hospital, Nanfang Medical University, Guangzhou, China; State Key Laboratory for Organ Failure ResearchSCI(E)PubMedARTICLEnlsun@263.net5627-6335