A concise gram-scale synthesis of ht-13-A via a rhodium-catalyzed intramolecular C-H activation reaction

The enantioselective total synthesis of the 3,4-fused indole alkaloid ht-13-A has been achieved. The synthesis features a zinc-mediated propargylation, a rhodium-catalyzed intramolecular C-H activation reaction, and a methylamine-mediated cyclization. This concise and efficient synthetic approach can be applied for the gram-scale synthesis of ht-13-A.National Natural Science Foundation of China [21372017, 21290183, 21572008]; State Key Laboratory of Bioorganic and Natural Products ChemistrySCI(E)PubMedARTICLEyxjia@bjmu.edu.cn7511300-113035